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Fig. 7 | BMC Cancer

Fig. 7

From: β2AR-HIF-1α-CXCL12 signaling of osteoblasts activated by isoproterenol promotes migration and invasion of prostate cancer cells

Fig. 7

Schematic illustration for ISO induced-osteoblasts activation and migration/invasion of prostate cancer cells. Osteoblasts respond to β2AR signaling activated by ISO to produce CXCL12 through upregulating the expresstion of HIF-1α. Osteoblast-drived CXCL12 binds to CXCR4 to promote migration and invasion as well as EMT of prostate cancer cells. β2AR, • β2 adrenegic receptor; ISO, isoproterenol; CXCL12, chemokine (C-X-C motif) ligand 12; CXCR4, chemokine (C-X-C motif) receptor type 4; HIF-1α, hypoxia inducible factor-1alpha; EMT, epithelial-mesenchymal transition

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BMC Cancer

ISSN: 1471-2407

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