Fig. 2

Functional enrichment analysis of differentially expressed transcripts of OS-DW cells a) Venn diagram showing number of transcripts involved in regulating different functional domains, categorized as per GO database, in the OS-DW cells, and the number of key genes which are common to all the three domains. b) Heatmap representing expression changes of the genes and pathways regulated by the key genes. The RNA-seq expression unit of each sample is taken in FPKM (Fragments Per Kilobase of transcripts per Million mapped reads) c) Cytoscape network showing the interaction of up- and down-regulated key genes through genetic linkers of the significant pathways in cancer. d) Bar graph representing significantly de-regulated pathways with above FC ≥ 10 in OS-DW cells compared to OS-R cells. Green bar represents down-regulation, whereas, red bars represent up-regulation. e) Heatmap showing expression of ABC transporters and platinum drug resistance associated genes in OS-DW cells in comparison to OS-R cells. f) Heatmap showing expression of genes associated with chromatin re-organization and DNA repair in OS-DW cells compared to OS-R cells. g) Bar graph showing diverse set of pathways that are up- (red) or down (green) regulated in OS-DW cells