Table 2 Toxicity results of triplet chemotherapy compared with doublet chemotherapy

 Neutropenia

131

748

18

184

651

28

0.62

0.51-0.76

682

1234

55

368

970

38

1.46

1.32-1.60

 Leucopenia

291

680

42

277

684

40

1.06

0.93-1.20

474

1102

43

252

885

28

1.51

1.33-1.71

 Anemia

498

925

53

454

924

49

1.10

1.00-1.20

111

784

14

123

682

18

0.79

0.62-0.99

 Thrombocytopenia

151

846

18

162

848

19

0.93

0.76-1.14

113

1181

9

119

934

12

0.75

0.59-0.96

 Febrile neutropenia

79

254

31

46

214

21

1.45

1.06-1.98

109

1026

10

44

774

6

1.87

1.33-2.62

 Nausea

358

584

61

353

491

71

0.85

0.78-0.93

115

1130

10

118

900

13

0.78

0.61-0.99

 Vomiting

295

716

41

275

622

44

0.93

0.82-1.06

74

795

9

70

618

11

0.82

0.60-1.12

 Diarrhea

343

748

46

201

651

31

1.49

1.29-1.71

125

1590

8

62

1323

5

1.68

1.25-2.25

 Stomatitis

254

716

35

165

622

27

1.34

1.14-1.58

151

1594

9

96

923

10

0.91

0.71-1.16

 Anorexia

150

467

32

138

376

36

0.88

0.73-1.06

57

546

10

41

452

9

1.15

0.79-1.69

 Fatigue

175

376

46

132

283

47

1.00

0.85-1.18

52

376

14

35

283

12

1.12

0.75-1.67

 Hand foot yndrome

45

259

17

32

168

19

0.91

0.61-1.37

17

376

5

7

237

3

1.53

0.64-3.64

 Sensory europathy

227

597

38

162

507

32

1.19

1.01-1.40

75

1021

7

49

805

6

1.21

0.85-1.71

 Alopecia

83

242

34

39

148

26

1.30

0.94-1.97

87

538

16

45

274

16

0.98

0.71-1.37

 Pigmentation

33

215

15

11

123

9

1.72

0.90-3.27

8

296

3

7

161

4

0.62

0.23-1.68

 Lethargy

83

221

37

74

224

33

1.14

0.88-1.46

57

300

19

45

300

15

1.27

0.89-1.81

 Infected

21

293

7

22

294

7

0.96

0.54-1.70

41

291

14

23

294

78

1.80

1.11-2.92

 Constipation

62

286

22

41

193

21

1.02

0.72-1.45

0

286

0

5

193

0.06

0.06

0.00-1.10

 Fluid retention

17

72

24

10

70

14

1.65

0.81-3.36

1

72

1.3

3

70

4

0.32

0.03-3.04

 Allergy

5

72

7

5

70

7

0.97

0.29-3.21

1

72

1.3

1

70

1.3

0.97

0.06-15.24

 Abdominal pain

33

170

19

21

78

27

0.72

0.45-1.16

6

170

3.5

4

78

5.1

0.69

0.20-2.37

 Increased ALT

28

149

19

28

144

19

0.97

0.60-1.55

0

149

0

1

144

0.6

0.32

0.01-7.85

 Increased AST

35

104

34

21

99

21

1.59

1.00-2.53

0

104

0

1

99

1

0.32

0.01-7.70

 Increased ALP

24

72

33

27

70

38

0.86

0.56-1.34

1

72

1.3

2

70

2.8

0.49

0.05-1.40

 Creatinine

18

149

12

26

144

18

0.67

0.38-1.17

1

149

0.6

0

144

0

2.90

0.12-7.61