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Fig. 4 | BMC Cancer

Fig. 4

From: Role of protein arginine methyltransferase 5 in group 3 (MYC-driven) Medulloblastoma

Fig. 4

Physical and functional interaction between PRMT5 and MYC. a HD-MB03 cell lysate was subjected to co-immunoprecipitation (IP) analysis using MYC antibody and control IgG, followed by immunoblotting with PRMT5 antibody. b HD-MB03 cell lysate was subjected to reciprocal co-immunoprecipitation using PRMT5 antibody and control IgG, followed by immunoblotting with MYC antibody. c Confocal images for the co-localization of MYC and PRMT5 in HD-MB03 cells and Group 3 medulloblastoma tumor tissue at 40x magnification. d Western blot analysis of MYC expression after 50 μg/ml CHX treatment following transient transfection of scrambled siRNA (SCR) and PRMT5-siRNA in HD-MB03 cells. e Densitometric quantification of MYC protein expression shown in “d”

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