Fig. 5

Predictive accuracy of the ROS scoring system compared with prognostic clinical factors. Receiver operating characteristic (ROC) analysis of the score and clinical covariates in predicting overall survival in TCGA (a), Tothill (b) and TJ (c) datasets. Using statistical models constructed based on multivariable Cox proportional hazards, ROC curves were calculated incorporating clinical variables of age, grade, and stage (left); age, grade, stage, and score (middle); and score alone (right). The area under the curve (AUC) was calculated for ROC curves, and sensitivity and specificity was calculated to assess the score performance.