Skip to main content
Fig. 3 | BMC Cancer

Fig. 3

From: MicroRNAs in Pancreatic Cancer: biomarkers, prognostic, and therapeutic modulators

Fig. 3

Schematic representation of mechanism of miR21 in PC development. miRNA-21 has previously been shown to target the expression of PTEN and PDCD4. Through inhibition of PTEN via miRNA-21, cell survival pathways are activated. With Akt pathway functionality heightened, the inhibition of BAD increases, which is a pro-apoptotic pathway, thus leading to a reduction in apoptosis. PTEN also inhibits angiogenesis within the VEGF pathway, thus miRNA-21 can enhance the establishment of new vasculature. Source: MS Powerpoint

Back to article page
\