Fig. 3

APOPTO-CELL model as a personalized risk assessment tool. a and b Patient-specific temporal profiles for substrate cleavage predicted by APOPTO-CELL (n = 46, a). The substrate cleavage reached at 15 min was deemed as the primary readout from the model simulations (b). Patients who did not cleave an amount of substrate of at least 80% were categorized as apoptosis-resistant (in red) whereas those above this threshold were classified as apoptosis-sensitive (in blue). c Association between apoptosis susceptibility predicted by APOPTO-CELL (SC ≤ 80% vs. SC > 80%, in red and blue, respectively) and type of tumor sample (newly-diagnosed and recurrent, light and dark shades, respectively). d-f Kaplan-Meier estimates of PFS in GBM patients categorized as apoptosis-resistant (n = 9, in red) or apoptosis-sensitive (n = 37 in blue) by APOPTO-CELL for the whole cohort (d) and stratified by type of tumor sample (newly-diagnosed and recurrent in e and f, respectively). P-values were determined by log-rank tests