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Table 2 This table shows the 20 genes that are in the set of conserved cisplatin-responsive gene set, and how those genes are up- and down-expressed in each of four Lehmann-identified TNBC subtypes. ‘UP’ indicates the gene is over-expressed and ‘DOWN’ indicates the gene is under-expressed. The ‘LAR’ or ‘M’ column indicates that the gene is differentially expressed in one of the two cisplatin-resistant subtypes compared with the BL1 or BL2 sensitive subtypes. The ‘Cell Death’ column indicates if the gene has been associated with a Gene Ontology term describing an aspect of cell death

From: Cisplatin-resistant triple-negative breast cancer subtypes: multiple mechanisms of resistance

Gene Symbol Gene Name BL1 BL2 M LAR Resistant Death
ABCC2 ATP binding cassette subfamily C member 2     UP *  
ADM adrenomedullin   UP UP    *
AKT1 AKT serine/threonine kinase 1     UP * *
BCL2 BCL2 apoptosis regulator DOWN      *
BCL2L1 BCL2 like 1     UP * *
CASP8 caspase 8    DOWN UP * *
CAV1 caveolin 1   UP     *
CLU clusterin DOWN    UP * *
FAS Fas cell surface death receptor    DOWN   * *
FOS Fos proto-oncogene, AP-1 transcription factor subunit DOWN      *
GSR glutathione-disulfide reductase     UP *  
GJA1 gap junction protein alpha 1 DOWN UP UP    *
HSPB1 heat shock protein family B (small) member 1   UP   UP   *
MSH2 mutS homolog 2 UP    DOWN * *
NOX4 NADPH oxidase 4 DOWN   UP   * *
NQO1 NAD(P)H quinone dehydrogenase 1     UP * *
PTK2 protein tyrosine kinase 2 UP      *
TUBA1A tubulin alpha 1a    UP DOWN *  
VCAM1 vascular cell adhesion molecule 1    DOWN   *  
VIM vimentin    UP DOWN *