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Table 2 This table shows the 20 genes that are in the set of conserved cisplatin-responsive gene set, and how those genes are up- and down-expressed in each of four Lehmann-identified TNBC subtypes. ‘UP’ indicates the gene is over-expressed and ‘DOWN’ indicates the gene is under-expressed. The ‘LAR’ or ‘M’ column indicates that the gene is differentially expressed in one of the two cisplatin-resistant subtypes compared with the BL1 or BL2 sensitive subtypes. The ‘Cell Death’ column indicates if the gene has been associated with a Gene Ontology term describing an aspect of cell death

From: Cisplatin-resistant triple-negative breast cancer subtypes: multiple mechanisms of resistance

Gene Symbol

Gene Name

BL1

BL2

M

LAR

Resistant

Death

ABCC2

ATP binding cassette subfamily C member 2

   

UP

*

 

ADM

adrenomedullin

 

UP

UP

  

*

AKT1

AKT serine/threonine kinase 1

   

UP

*

*

BCL2

BCL2 apoptosis regulator

DOWN

    

*

BCL2L1

BCL2 like 1

   

UP

*

*

CASP8

caspase 8

  

DOWN

UP

*

*

CAV1

caveolin 1

 

UP

   

*

CLU

clusterin

DOWN

  

UP

*

*

FAS

Fas cell surface death receptor

  

DOWN

 

*

*

FOS

Fos proto-oncogene, AP-1 transcription factor subunit

DOWN

    

*

GSR

glutathione-disulfide reductase

   

UP

*

 

GJA1

gap junction protein alpha 1

DOWN

UP

UP

  

*

HSPB1

heat shock protein family B (small) member 1

 

UP

 

UP

 

*

MSH2

mutS homolog 2

UP

  

DOWN

*

*

NOX4

NADPH oxidase 4

DOWN

 

UP

 

*

*

NQO1

NAD(P)H quinone dehydrogenase 1

   

UP

*

*

PTK2

protein tyrosine kinase 2

UP

    

*

TUBA1A

tubulin alpha 1a

  

UP

DOWN

*

 

VCAM1

vascular cell adhesion molecule 1

  

DOWN

 

*

 

VIM

vimentin

  

UP

DOWN

*

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