Genetic and clinical characterization of BRCA-associated hereditary breast and ovarian cancer in Navarra (Spain)

Table 4 Overall survival rates for breast and ovarian cancer

	Number	Mean age at death	Overall Survival			Log Rank test	Age adjusted
	Number	Mean age at death	5-year	10-year	15-year	Log Rank test	Hazard Ratio (95% CI)	P-value
Breast Cancer
BRCA1+	30	58.79 ± 13.96	0.863	0.823	0.640	p < 0.001	3.19 (1.51, 6.74)	0.002
BRCA2+	53	53.4 ± 11.06	0.882	0.786	0.703		2.63 (1.48, 4.67)	0.001
2High risk BRCA-	327	50.73 ± 11.87	0.948	0.899	0.840		1.1 (0.79, 1.54)	0.578
Low risk	120	55.41 ± 11.49	0.967	0.936	0.874		0.61 (0.33, 1.14)	0.122
Cancer Registry	4384	77.12 ± 15.83	0.818	0.724	0.651		Reference
Ovarian Cancer
BRCA1+	13	62.68 ± 13.43	0.615	0.538	0.202	p < 0.001	–
BRCA2+	7	53.93	0.857	0.857	0.857
High risk BRCA-	27	64.1 ± 10.05	0.889	0.572	0.525
Low risk	8	64.46 ± 12.27	0.875	0.500	0.333
Cancer Registry	561	72.85 ± 12.37	0.408	0.321	0.276

ISSN: 1471-2407