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Table 3 Clinical characteristics of breast and ovarian cancer cases included in the study

From: Genetic and clinical characterization of BRCA-associated hereditary breast and ovarian cancer in Navarra (Spain)

 Hereditary breast/ovarian cancer studyCancer RegistryP-value
High risk BRCA1+
n (%)
High risk BRCA2+
n (%)
High risk BRCA-
n (%)
Low risk
n (%)
Breast cancer
 Laterality
  Right11 (37.9%)22 (41.5%)153 (48.1%)51 (44%)2003 (47.4%) 
  Left17 (58.6%)27 (50.9%)155 (48.7%)61 (52.6%)2142 (50.7%) 
  Bilateral1 (3.5%)4 (7.6%)10 (3.2%)4 (3.5%)78 (1.8%)0.021 (a)
  Total29533181164223 
(a) BRCA2+ vs Cancer Registry: OR = 4.3; 95% CI = 1.3 to 11.4
 Stage
  Localized10 (40%)24 (47.1%)154 (57.2%)56 (59.6%)2396 (57%) 
  Regional13 (52%)24 (47.1%)105 (39%)36 (38.3%)1618 (38.5%) 
  Advanced2 (8%)3 (5.9%)10 (3.7%)2 (2.1%)189 (4.5%)0.043 (b)
  Total2551269944203 
(b) BRCA1/2 vs Cancer Registry
 Age at diagnosis in years
  Mean (standard deviation)44.3 (8.98)44.12 (10.17)45.72 (10.34)50.14 (11.44)60.79 (15.47) 
  Number30533271204384 
  p-value< 0.001< 0.001< 0.001< 0.001Reference 
Ovarian cancer
 Laterality
  Right1 (11.1%)06 (46.2%)3 (60%)100 (37.2%) 
  Left1 (11.1%)2 (66.7%)3 (23.1%)2 (40%)86 (32%) 
  Bilateral7 (77.8%)1 (33.3%)4 (30.8%)083 (30.9%)0.007 (c)
  Total93135269 
(c) BRCA1+ vs Cancer Registry: OR = 7.8; 95% CI = 1.7 to 55.7
 Stage
  Localized1 (9.1%)1 (25%)6 (25%)2 (28.6%)28 (23%) 
  Advanced10 (90.9%)3 (75%)18 (75%)5 (71.4%)94 (77%)0.43 (d)
  Total114247122 
(d) BRCA1/2 vs Cancer Registry
 Age at diagnosis in years
  Mean (standard deviation)54.12 (12.03)53.33 (14.68)53.29 (10.86)54.55 (13.08)65.63 (15.43) 
  Number137278561 
  p-value0.0070.078< 0.0010.057Reference