Table 1 Patient characteristics
Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 | Patient 6 | Patient 7 | Patient 8 | Patient 9 | |
|---|---|---|---|---|---|---|---|---|---|
Initial Diagnosis | June 2018 | March 2014 | July 2017 | February 2017 | May 2017 | June 2016 | May 2013 | March 2013 | August 2016 |
Primary | |||||||||
localization | rectum | rectum | rectum | rectum | caecum | rectum | rectum | rectum | CUP/iCRC |
date resection | June 2019 | Mar 2014 | Oct 2017 | June 2017 | May 2017 | Nov 2016 | June 2013 | Mar 2013 | n.a. |
pTNM | pT3 pN1b pM1a (HEP) | ypT2 pN0 cM0 | ypT3 pN0 cM0 | ypT2 ypN1a cM0 | pT3 pN1a cM0 | ypT4b ypN1b cM0 | pT4b pN1a pM1a(HEP) | pT3 pN0 cM0 | n.a. |
L/V/Pn | L1, V1, Pn0, | L0, V0, Pn0 | L0, V0, Pn0 | L0, V0, Pn0 | L0, V1, Pn0 | L1, V1, Pn1 | V0, L1, Pn1 | L1, V0, Pn0 | n.a. |
UICC-stage | IVA | I | II | IIIA | IIIB | IIIC | IVA | IVA | n.a. |
Hepatic Metastasis | |||||||||
date resection | Nov 2018 | May 2018 | July 2018 | Aug 2018 | Aug 2018 | Sep 2018 | Aug 2017 | Aug 2017 | July 2017 |
synchronous - 0, metachronous - 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | n.a. |
Molecular biology | |||||||||
KRAS | WT | mutation G12D | mutation G12A | mutation G13D | WT | WT | WT | WT | WT |
NRAS | WT | WT | WT | WT | WT | WT | WT | mutation G13R “c37G > C” | WT |
BRAF | WT | WT | WT | WT | WT | WT | WT | WT | WT |
MS-stability | MSS | MSS | MSS | MSS | MSS | MSS | MSS | MSS | MSS |
Systemic therapy* | yes | yes | yes | yes | no | yes | yes | no | yes |
Checkpoint Inhibition | |||||||||
PDL-1 IC% | 50 | 23 | 13 | 21 | 16 | 25 | 5 | 6 | 51 |
PDL-1 TC% | 0.1 | 0.5 | 0.1 | 2.5 | 0.5 | 0.2 | 0 | 0 | 2 |
PDL-1 CPS | 50.1 | 23.5 | 13.1 | 23.5 | 16.5 | 25.2 | 5 | 6 | 53 |
PD1 IC% | 36 | 25 | 29 | 20 | 41 | 31 | 35 | 21 | 34 |
Death | no | no | no | no | no | no | no | no | no |
Recurrence** | Jan 2019 (PUL) | no | no | no | no | no | no | no | Aug 2017 (THO) Feb 2018 (OSS) May 2018 (HEP) |