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Table 5 Univariate cox regression analysis of OS

From: Tumor budding outperforms ypT and ypN classification in predicting outcome of rectal cancer after neoadjuvant chemoradiotherapy

 

Overall survival

Parameter

HR

95% CI

P

Age

1.06

[1.01; 1.10]

0.010

Male vs. female

0.54

[0.25; 1.16]

0.114

BMI

0.97

[0.84; 0;97]

0.006

ASA 2 and 3

2.21

[0.52; 9.37]

0.282

cM1

6.53

[2.74; 15.54]

0.001

Type of resection: APR vs. LAR

1.77

[0.80; 3.89]

0.156

Adjuvant therapy

1.23

[0.45; 3.37]

0.681

Tumor size

1.01

[0.98; 1.03]

0.554

CRM

0.95

[0.90; 0.99]

0.043

Poor Quirke Grade

2.72

[1.47; 2.47]

0.001

Higher ypT stage [ypT3–4]

3.01

[1.20; 7.55]

0.019

ypN+

1.64

[0.74; 3.63]

0.220

Histological Grading

2.24

[1.26; 3.97]

0.006

Tumor regression Grading

0.19

[0.07; 0.51]

0.001

Budding positive H&E

3.43

[1.57; 7.52]

0.002

Budding positive IHC

5.76

[1.95; 17.01]

0.002

V1

1.60

[0.64; 3.99]

0.316

L1

1.90

[0.70; 5.18]

0.209

Pn1

3.76

[1.60; 8.85]

0.002

R+

1.01

[0.14; 7.49]

0.993

  1. Abbreviations: OS overall survival, HR hazard ratio, 95% CI 95% confidence interval, P P-value, BMI body mass index, ASA American Society of Anesthesiologists, APR abdominoperineal excision, LAR low anterior resection, CRM circumferential resection margin, Pn1 perineural invasion, R+ = invaded margin. Significant p-values and corresponding hazard ratios are represented in bold type
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BMC Cancer

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