Budding on H&E | Budding on IHC | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
negative | positive | P | negative | positive | P | |||||
All patients, n (%) | 65 | (63.1) | 38 | (36.9) | 44 | (44.4) | 55 | (55.6) | ||
Age | ||||||||||
Mean, years (SD) | 62.5 | (9.2) | 67.1 | (10.8) | 0.032 | 61.8 | (9.8) | 65.7 | (9.8) | 0.055 |
Sex, n (%) | ||||||||||
Male | 48 | (65.8) | 25 | (34.2) | 0.501 | 34 | (47.9) | 37 | (52.1) | 0.370 |
Female | 17 | (56.7) | 13 | (43.3) | 10 | (35.7) | 18 | (64.3) | ||
BMI | ||||||||||
Mean, kg/m2 (SD) | 25.8 | (3.9) | 23.6 | (5.7) | 0.042 | 25.6 | (3.2) | 24.6 | (5.6) | 0.252 |
ASA classification, n (%) | ||||||||||
1 | 12 | (85.7) | 2 | (14.3) | 0.022 | 9 | (64.3) | 5 | (35.7) | 0.096 |
2 | 47 | (64.4) | 26 | (35.6) | 31 | (44.9) | 38 | (55.1) | ||
3 | 6 | (37.5) | 10 | (62.5) | 4 | (25.0) | 12 | (75.0) | ||
cT stage, n (%) | ||||||||||
T0–1 | – | – | – | – | 0.005 | – | – | – | – | 0.011 |
T2 | 5 | (55.6) | 4 | (44.4) | 2 | (22.2) | 7 | (77.8) | ||
T3 | 54 | (72.0) | 21 | (28.0) | 39 | (53.4) | 34 | (46.6) | ||
T4 | 6 | (31.6) | 13 | (68.4) | 3 | (17.6) | 14 | (82.4) | ||
cN stage, n (%) | ||||||||||
N0 | 7 | (70.0) | 3 | (30.0) | 0.742 | 7 | (70.0) | 3 | (30.0) | 0.104 |
N+ | 58 | (62.4) | 35 | (37.6) | 37 | (41.6) | 52 | (58.4) | ||
cM stage, n (%) | ||||||||||
M0 | 60 | (66.7) | 30 | (33.3) | 0.066 | 42 | (47.2) | 47 | (52.8) | 0.178 |
M1 | 5 | (38.5) | 8 | (61.5) | 2 | (20.0) | 8 | (80.0) | ||
Type of resection, n (%) | ||||||||||
LAR | 53 | (71.6) | 21 | (28.4) | 0.004 | 39 | (53.4) | 34 | (46.6) | 0.003 |
APR | 12 | (41.4) | 17 | (58.6) | 5 | (19.2) | 21 | (80.8) | ||
Adjuvant therapy, n (%) | ||||||||||
Yes | 42 | (66.7) | 21 | (33.3) | 0.218 | 27 | (45.0) | 33 | (55.0) | 0.741 |
No | 12 | (52.2) | 11 | (47.8) | 9 | (40.9) | 13 | (59.1) | ||
Not described | 11 | 6 | 8 | 9 | ||||||
Relapse in the follow-up period, n (%) | ||||||||||
No | 57 | (71.3) | 23 | (28.7) | 0.002 | 41 | (53.9) | 35 | (46.1) | 0.001 |
Yes | 8 | (34.8) | 15 | (65.2) | 3 | (13.0) | 20 | (87.0) | ||
Type of relapse, n (%) | ||||||||||
Local recurrence | 2 | (50.0) | 2 | (50.0) | 0.015 | 1 | (25.0) | 3 | (75.0) | 0.003 |
Liver | 2 | (28.6) | 5 | (71.4) | 0 | (0) | 7 | (100) | ||
Lung | 3 | (33.3) | 6 | (66.7) | 1 | (11.1) | 8 | (88.9) | ||
Cerebral | 1 | (33.3) | 2 | (66.7) | 1 | (33.3) | 2 | (66.7) | ||
Survival status in follow-up, n (%) | ||||||||||
Alive | 54 | (71.1) | 22 | (28.9) | 0.006 | 40 | (53.3) | 35 | (46.7) | 0.002 |
Dead | 11 | (40.7) | 16 | (59.3) | 4 | (16.7) | 20 | (83.3) |