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Fig. 2 | BMC Cancer

Fig. 2

From: Tumor budding outperforms ypT and ypN classification in predicting outcome of rectal cancer after neoadjuvant chemoradiotherapy

Fig. 2

Comparison of tumor budding in neoadjuvant treated rectal cancers in both hematoxylin-eosin and in immunohistochemical staining. Tumor budding was defined as a single tumor cell or a cluster up to four tumor cells at the invasive front or within the tumor as well. Tumor buds were counted in one field measuring 0.785 mm2 using a 20x objective lens. A field with 4 buds or fewer was viewed as budding negative (a-d), a field with 5 or more buds was viewed as budding positive (e-h). Boxed areas are shown in a higher magnification on the right side of the corresponding picture. (Original magnification and staining method: (a) × 40, H&E; (b) × 200, H&E; (c) × 40, AE1/AE3; (d) × 200, AE1/AE3; (e) × 40, H&E; (f) × 200, H&E; (g) × 40, AE1/AE3; (h) × 200, AE1/AE3;)

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BMC Cancer

ISSN: 1471-2407

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