Fig. 3

The expression of caspase-3, caspase-9, TLR2, NF-κB p56, GSK3β, Akt was assessed by western blot (* P < 0.05, ** P < 0.01). a The expression of the molecules, normalized by GADPH. b~c The expression of caspase-3 and caspase-9 in Arr2+ mice and control with different dosage of paclitaxel treatment was shown In Arr2+ mice, 20 mg paclitaxel group has significantly higher level of caspase-9 expression than 0 mg group(P = 0.003). In the control, significant effect can be seen between 20 mg and 0 mg group in caspase-3 (P = 0.007) and between both 0 mg, 10 mg (P = 0.012) and 0 mg, 20 mg group (=0.002) in caspase-9. d The expression of TLR2 in each group was shown. Both 20 mg(P = 0.000) and 10 mg(P = 0.003) paclitaxel group show significance comparing to 0 mg group in Arr2+ mice, which is not shown in control group. (e~g) The expression of NF-κB, GSK3β and Akt in each group was shown. There was no significance between each treatment group in Arr2+ and control mice, except 20 mg and 0 mg group in control mice (P = 0.022)