Fig. 1

Tumor volume and tumor weight after paclitaxel treatment (*P < 0.05, ** p < 0.01). a Tumor volume in each group was monitored from D14 to D28. b Tumor weight was measured after sacrificing on D28. In both control and Arr2+ mice, 10 mg(P = 0.002, P = 0.000, respectively) and 20 mg(P = 0.000, both) paclitaxel treatment led to a significant lower level of tumor weight comparing to 0 mg treatment. c Mice of both groups with tumor heterotransplants in the right ampit after sacrificing on D28. d Tumor heterotransplants of both groups after sacrificing on D28