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Table 2 Relationship between SMAD4 expression and clinic pathological features

From: SMAD4 Y353C promotes the progression of PDAC

Group SMAD4 expression χ2 p-value
Intact SMAD4 Lost SMAD4
Sex
 Male 8 (34.78%) 25 (34.7%) <0.001 1.000
 Female 15 (65.22%) 47 (65.3)   
Age (year)
 <60 11 (47.8%) 19 (26.4%) 3.708 0.072
 ≥60 12 (52.2%) 53 (73.6%)   
Tumor diameter (cm)
 <3 11 (47.8%) 15 (20.8%) 6.389 0.016
 ≥3 12 (52.2%) 57 (79.2%)   
TNM tumor staging
 IA~IIA 21 (91.3%) 46 (63.9%) 6.303 0.016
 IIB~IV 2 (8.7%) 26 (36.1%)   
Lymphatic invasion
 Yes 2 (8.7%) 70 (97.2%) 74.451 <0.001
 No 21 (91.3%) 2 (2.8%)   
Tumor location
 Head 11 (47.8%) 47 (65.3%) 2.233 0.149
 Body and tail 12 (52.2%) 25 (34.7%)   
Differentiation
 High and middle differentiation 12 (52.2%) 19 (26.4%) 5.272 0.039
 Poorly differeftiation 11 (47.8%) 53 (73.6%)   
Perineural invasion
 Yes 9 (39.1%) 22 (30.6%) 0.583 0.610
 No 14 (60.9%) 50 (69.4%)   
  1. The bold values indicate P values less than 0.05