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Table 2 Comparisons of the clinicopathologic features between classical adenocarcinoma and other histologic types, including mucinous adenocarcinoma, signet-ring cell carcinoma and adenocarcinoma with mixed subtypes

From: Adenocarcinoma with mixed subtypes is a rare but aggressive histologic subtype in colorectal cancer

Characteristics (N)Classical adenocarcinoma N (%)Mucinous adenocarcinoma N (%)P1aP2aSignet-ring cell carcinoma N (%)P1aP2aAdenocarcinoma with mixed subtypes N (%)P1a
Gender  <  0.0010.05 0.110.33 0.89
Male8511 (53.8)2759 (48.5)  415 (51.0)  175 (54.2) 
Female7301 (46.2)2930 (51.5)  399 (49.0)  147 (45.8) 
Age (yrs, median: 66)  <  0.0010.59 0.530.06 0.07
≤ 668894 (56.2)2818 (49.5)  467 (57.4)  164 (54.5) 
>  666918 (43.8)2871 (50.5)  347 (42.6)  157 (45.5) 
Tumor location  <  0.0010.29 <  0.0010.76 <  0.001
Colon12,198 (77.1)5055 (88.9)  713 (87.6)  279 (86.9) 
Rectum3614 (22.9)634 (11.1)  101 (12.4)  42 (13.1) 
Grade  <  0.001<  0.001 <  0.001<  0.001 <  0.001
Well differentiated2308 (17.6)705 (13.4)  8 (1.1)  4 (1.4) 
Moderately differentiated9491 (72.6)3344 (63.7)  58 (8.0)  53 (18.0) 
Poorly differentiated or undifferentiated1278 (9.8)1199 (22.8)  656 (90.9  237 (80.6) 
Primary tumor size (cm)  <  0.0010.76 <  0.0010.48 <  0.001
≤ 47754 (71.7)1628 (31.3)  223 (32.8)  89 (30.5) 
>  43148 (28.9)3568 (68.7)  457 (67.2)  203 (69.5) 
CEA  <  0.0010.06 <  0.0010.52 <  0.001
Normal4804 (69.9)1558 (46.4)  217 (42.4)  76 (39.2) 
Borderline25 (0.4)29 (0.9)  3 (0.6)  3 (1.5) 
Elevated2043 (29.7)1770 (52.7)  292 (57.0)  115 (59.3) 
T category  <  0.001<  0.001 <  0.0010.29 <  0.001
Tis1988 (12.6)21 (0.4)  4 (0.5)  0 (0.0) 
T17516 (47.5)309 (5.4)  45 (5.5)  11 (3.4) 
T22168 (13.7)547 (9.6)  34 (4.2)  21 (6.5) 
T33316 (21.0)3120 (55.0)  341 (42.0)  150 (46.7) 
T4822 (5.2)1680 (29.6)  388 (47.8)  139 (43.3) 
N category  <  0.001<  0.001 <  0.0010.27 <  0.001
N012,776 (80.8)3130 (55.0)  251 (30.8)  110 (34.3) 
N12244 (14.2)1405 (24.7)  176 (21.6)  68 (21.2) 
N2792 (5.0)1154 (20.3)  387 (47.5)  143 (44.5) 
M category  <  0.0010.002 <  0.0010.01 <  0.001
M014,931 (94.4)4505 (79.2)  519 (63.8)  231 (72.0) 
M1881 (5.6)1184 (20.8)  295 (36.2)  90 (28.0) 
CRM  <  0.001<  0.001 <  0.0010.60 <  0.001
Negative5685 (85.7)2163 (73.7)  220 (62.1)  101 (59.8) 
Positive950 (14.3)770 (26.3)  134 (37.9)  68 (40.2) 
Perineural invasion  <  0.001<  0.001 <  0.0010.003 <  0.001
Negative12,234 (95.6)3957 (89.7)  383 (70.8)  201 (80.7) 
Positive569 (4.4)454 (10.3)  158 (29.2)  48 (19.3) 
Tumor deposits  <  0.001<  0.001 <  0.0010.21 <  0.001
Absent12,369 (95.2)4161 (84.1)  421 (67.5)  197 (71.6) 
Present622 (4.8)786 (15.9)  203 (32.5)  78 (28.4) 
  1. Abbreviation: CEA carcinoembryonic antigen, CRM circumferential resection margin
  2. a P1, comparisons using “classical adenocarcinoma” as the reference. P2, comparisons using “adenocarcinoma with mixed subtypes” as the reference