Table 2 Comparisons of the clinicopathologic features between classical adenocarcinoma and other histologic types, including mucinous adenocarcinoma, signet-ring cell carcinoma and adenocarcinoma with mixed subtypes
From: Adenocarcinoma with mixed subtypes is a rare but aggressive histologic subtype in colorectal cancer
Characteristics (N) | Classical adenocarcinoma N (%) | Mucinous adenocarcinoma N (%) | P1a | P2a | Signet-ring cell carcinoma N (%) | P1a | P2a | Adenocarcinoma with mixed subtypes N (%) | P1a |
|---|---|---|---|---|---|---|---|---|---|
Gender | < 0.001 | 0.05 | 0.11 | 0.33 | 0.89 | ||||
Male | 8511 (53.8) | 2759 (48.5) | 415 (51.0) | 175 (54.2) | |||||
Female | 7301 (46.2) | 2930 (51.5) | 399 (49.0) | 147 (45.8) | |||||
Age (yrs, median: 66) | < 0.001 | 0.59 | 0.53 | 0.06 | 0.07 | ||||
≤ 66 | 8894 (56.2) | 2818 (49.5) | 467 (57.4) | 164 (54.5) | |||||
> 66 | 6918 (43.8) | 2871 (50.5) | 347 (42.6) | 157 (45.5) | |||||
Tumor location | < 0.001 | 0.29 | < 0.001 | 0.76 | < 0.001 | ||||
Colon | 12,198 (77.1) | 5055 (88.9) | 713 (87.6) | 279 (86.9) | |||||
Rectum | 3614 (22.9) | 634 (11.1) | 101 (12.4) | 42 (13.1) | |||||
Grade | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | ||||
Well differentiated | 2308 (17.6) | 705 (13.4) | 8 (1.1) | 4 (1.4) | |||||
Moderately differentiated | 9491 (72.6) | 3344 (63.7) | 58 (8.0) | 53 (18.0) | |||||
Poorly differentiated or undifferentiated | 1278 (9.8) | 1199 (22.8) | 656 (90.9 | 237 (80.6) | |||||
Primary tumor size (cm) | < 0.001 | 0.76 | < 0.001 | 0.48 | < 0.001 | ||||
≤ 4 | 7754 (71.7) | 1628 (31.3) | 223 (32.8) | 89 (30.5) | |||||
> 4 | 3148 (28.9) | 3568 (68.7) | 457 (67.2) | 203 (69.5) | |||||
CEA | < 0.001 | 0.06 | < 0.001 | 0.52 | < 0.001 | ||||
Normal | 4804 (69.9) | 1558 (46.4) | 217 (42.4) | 76 (39.2) | |||||
Borderline | 25 (0.4) | 29 (0.9) | 3 (0.6) | 3 (1.5) | |||||
Elevated | 2043 (29.7) | 1770 (52.7) | 292 (57.0) | 115 (59.3) | |||||
T category | < 0.001 | < 0.001 | < 0.001 | 0.29 | < 0.001 | ||||
Tis | 1988 (12.6) | 21 (0.4) | 4 (0.5) | 0 (0.0) | |||||
T1 | 7516 (47.5) | 309 (5.4) | 45 (5.5) | 11 (3.4) | |||||
T2 | 2168 (13.7) | 547 (9.6) | 34 (4.2) | 21 (6.5) | |||||
T3 | 3316 (21.0) | 3120 (55.0) | 341 (42.0) | 150 (46.7) | |||||
T4 | 822 (5.2) | 1680 (29.6) | 388 (47.8) | 139 (43.3) | |||||
N category | < 0.001 | < 0.001 | < 0.001 | 0.27 | < 0.001 | ||||
N0 | 12,776 (80.8) | 3130 (55.0) | 251 (30.8) | 110 (34.3) | |||||
N1 | 2244 (14.2) | 1405 (24.7) | 176 (21.6) | 68 (21.2) | |||||
N2 | 792 (5.0) | 1154 (20.3) | 387 (47.5) | 143 (44.5) | |||||
M category | < 0.001 | 0.002 | < 0.001 | 0.01 | < 0.001 | ||||
M0 | 14,931 (94.4) | 4505 (79.2) | 519 (63.8) | 231 (72.0) | |||||
M1 | 881 (5.6) | 1184 (20.8) | 295 (36.2) | 90 (28.0) | |||||
CRM | < 0.001 | < 0.001 | < 0.001 | 0.60 | < 0.001 | ||||
Negative | 5685 (85.7) | 2163 (73.7) | 220 (62.1) | 101 (59.8) | |||||
Positive | 950 (14.3) | 770 (26.3) | 134 (37.9) | 68 (40.2) | |||||
Perineural invasion | < 0.001 | < 0.001 | < 0.001 | 0.003 | < 0.001 | ||||
Negative | 12,234 (95.6) | 3957 (89.7) | 383 (70.8) | 201 (80.7) | |||||
Positive | 569 (4.4) | 454 (10.3) | 158 (29.2) | 48 (19.3) | |||||
Tumor deposits | < 0.001 | < 0.001 | < 0.001 | 0.21 | < 0.001 | ||||
Absent | 12,369 (95.2) | 4161 (84.1) | 421 (67.5) | 197 (71.6) | |||||
Present | 622 (4.8) | 786 (15.9) | 203 (32.5) | 78 (28.4) |