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Table 7 Clinical features of AFF cases published in the literature

From: Atypical femoral fracture in patients with bone metastasis receiving denosumab therapy: a retrospective study and systematic review

Journal

Age/Gender

Primary disease

Exposure to other BMA

Duration of denosumab treatment

Diagnosis

Operation (treatment)

Yang et al. The oncologist (2017)

70/F

Breast Ca.

Alendronate, Risedronate

23 months

Rt. AFF

Intramedullary rod placement

Ota et al. Breast Cancer (2017)

73/F

Breast Ca.

Zoledronic acid

54 months

Bilateral AFF

 

Sugihara et al. Clin Nucl Med (2018)

59/F

Breast Ca.

None

4 years (48 months)

Rt. impending AFF or AFSR

 

Koizumi et al. Clin Nucl Med (2017)

53/F

Thyroid Ca.

Bisphosphonate

1.5 years (18 months)

Lt. impending AFF

 

Tateiwa et al. Journal of orthopaedic surgery (2017)

52/F

Breast Ca.

Pamidronate, Zoledronate

2 years and 3 months (27 months)

Bilateral AFF

Intramedullary nail was placed

Austin et al. Acta Orthopedica (2017)

75/F

Breast Ca.

NSCLC

None

2 years (24 months)

Bilateral AFF

Intramedullary fixation

86/M

Prostate Ca.

None

3.5 years (42 months)

Rt. AFF