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Table 2 Patient characteristics

From: Atypical femoral fracture in patients with bone metastasis receiving denosumab therapy: a retrospective study and systematic review

 

Number of patients

Characteristics

n = 277, n (%)

Age, median (range)

median 65 (29–88)

Gender

 Male

93 (34)

 Female

184 (66)

Primary disease

 Breast cancer

159 (57)

 Prostate cancer

26 (9)

 Pancreatic cancer

13 (5)

 Lung cancer

12 (4)

 RCC

12 (4)

 Gastric cancer

11 (4)

 Carcinoma of unknown primary

8 (3)

 Colorectal cancer

8 (3)

 Esophageal cancer

5 (2)

 Urothelial cancer

4 (1)

 Melanoma

2 (1)

 Hepatocellular carcinoma

2 (1)

 Others

15 (5)

Stage at diagnosis

 I

21 (8)

 II

58 (22)

 III

46 (17)

 IV

94 (35)

 Unknown

46 (17)

Perioperative chemotherapy

 Yes

80 (29)

 No

195 (70)

 Unknown

2 (1)

Metastatic site

 Lung

120 (43)

 Liver

107 (39)

 Lymph node

147 (53)

 Bone

277 (100)

 Brain

28 (10)

 Pleura

23 (8)

 Peritoneum

20 (7)

 Adrenal gland

17 (6)

 Others

19 (7)

Prior zoledronic acid treatment

 Yes

56 (20)

 No

167 (60)

 Unknown

54 (19)

Number of doses of denosumab

median 10 (1–79)

More than 45 doses of denosumab

16 (5)