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Table 2 Patient characteristics

From: Atypical femoral fracture in patients with bone metastasis receiving denosumab therapy: a retrospective study and systematic review

  Number of patients
Characteristics n = 277, n (%)
Age, median (range) median 65 (29–88)
Gender
 Male 93 (34)
 Female 184 (66)
Primary disease
 Breast cancer 159 (57)
 Prostate cancer 26 (9)
 Pancreatic cancer 13 (5)
 Lung cancer 12 (4)
 RCC 12 (4)
 Gastric cancer 11 (4)
 Carcinoma of unknown primary 8 (3)
 Colorectal cancer 8 (3)
 Esophageal cancer 5 (2)
 Urothelial cancer 4 (1)
 Melanoma 2 (1)
 Hepatocellular carcinoma 2 (1)
 Others 15 (5)
Stage at diagnosis
 I 21 (8)
 II 58 (22)
 III 46 (17)
 IV 94 (35)
 Unknown 46 (17)
Perioperative chemotherapy
 Yes 80 (29)
 No 195 (70)
 Unknown 2 (1)
Metastatic site
 Lung 120 (43)
 Liver 107 (39)
 Lymph node 147 (53)
 Bone 277 (100)
 Brain 28 (10)
 Pleura 23 (8)
 Peritoneum 20 (7)
 Adrenal gland 17 (6)
 Others 19 (7)
Prior zoledronic acid treatment
 Yes 56 (20)
 No 167 (60)
 Unknown 54 (19)
Number of doses of denosumab median 10 (1–79)
More than 45 doses of denosumab 16 (5)
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