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Table 1 Baseline Patient and Tumor Characteristics

From: Incidence and risk factors for acute kidney injury in head and neck cancer patients treated with concurrent chemoradiation with high-dose cisplatin

CharacteristicTotal (N = 124)AKI (n = 85)Non-AKI (n = 39)
Median age, (range), years60 (30–74)60 (30–71)59 (41–74)
Male97 (78)67 (79)30 (77)
ECOG performance status
 041 (33)26 (31)15 (38)
 176 (61)55 (65)21 (54)
 26 (5)3 (4)3 (8)
 Not specified1 (1)1 (1)
 Hypertension25 (20)20 (24)5 (13)
 Diabetes mellitus9 (7)7 (8)2 (5)
 Cognitive impairment8 (6)4 (5)4 (10)
CCI
 0–192 (74)61 (72)31 (79)
 2–332 (26)24 (28)8 (21)
Smoking
  ≥ 10 pack-years92 (74)65 (76)27 (69)
Alcohol
  ≥ 14 Units/week46 (37)35 (41)11 (28)
 Number of nephrotoxic co-medications, median (range)2 (0–3)2 (0–3)2 (1–3)
 Mean SCr (SD), μmol/l66 (12)66 (12)65 (12)
Primary site
 Oral cavity / oropharynx88 (71)58 (68)30 (77)
 Hypopharynx15 (12)12 (14)3 (8)
 Larynx17 (14)12 (14)5 (13)
 Other4 (3)3 (4)1 (3)
Tumor stage
 T1–246 (37)29 (34)17 (44)
 T3–469 (56)51 (60)18 (46)
 Unknown6 (5)5 (6)1 (3)
Nodal stage
 N015 (12)12 (14)3 (8)
 N+106 (85)71 (84)35 (90)
 Unknown3 (2)2 (2)1 (3)
  1. Data given as No. (%), unless otherwise noted
  2. Abbreviations: ECOG Eastern Cooperative Oncology Group Performance Status Score (WHO), CCI Age-adjusted Charlson Comorbidity Index, SCr Serum creatinine (μmol/L), SD standard deviation