Table 1 Correlation of HDGF, VEGF and clinicopathological data
From: Novel HDGF/HIF-1α/VEGF axis in oral cancer impacts disease prognosis
Parameters | HDGF-N | P value | HDGF-C | P value | VEGF | P value | |
|---|---|---|---|---|---|---|---|
Gender | Male | 50.0 ± 24.7 | 0.368 | 56.6 ± 25.1 | 0.650 | 67.0 ± 27.4 | 0.815 |
Female | 36.6 ± 40.4 | 63.3 ± 30.6 | 63.3 ± 15.3 | ||||
Age (years) | r = 0.126 | 0.223 | r = 0.112 | 0.281 | r = 0.04 | 0.970 | |
Primary tumor (T) | T1-T2 | 41.2 ± 21.6 | 0.004* | 53.6 ± 27.6 | 0.166 | 61.02 ± 27.9 | 0.038* |
T3 | 45.3 ± 24.1 | 54.7 ± 23.0 | 68.3 ± 28.4 | ||||
T4 | 59.2 ± 27.1 | 61.5 ± 22.4 | 73.6 ± 24.8 | ||||
Nodal status (N) | N0 | 49.7 ± 22.6 | 0.924 | 54.6 ± 26.8 | 0.814 | 59.3 ± 23.6 | 0.021* |
N1 | 50.3 ± 20.2 | 64.7 ± 24.9 | 67.7 ± 27.9 | ||||
N2 | 40.2 ± 28.9 | 55.9 ± 23.8 | 73.3 ± 28.3 | ||||
Extracapsular extension of metastatic nodes | Present | 54.7 ± 29.6 | 0.149 | 58.7 ± 26.3 | 0.996 | 77.3 ± 25.5 | 0.052 |
Absent | 44.9 ± 24.7 | 58.7 ± 23.3 | 63.7 ± 29.4 | ||||
Histological grade | W-D | 40.9 ± 25.1 | 0.013* | 61.9 ± 24.3 | 0.061 | 58.1 ± 23.7 | 0.017* |
M-D | 53.6 ± 22.9 | 57.6 ± 26.6 | 75.7 ± 24.4 | ||||
P-D | 59.1 ± 24.6 | 45.9 ± 21.9 | 68.8 ± 32.5 | ||||
Vascular invasion | Present | 55.2 ± 27.1 | 0.205 | 57.1 ± 27.3 | 0.948 | 71.7 ± 25.9 | 0.325 |
Absent | 47.7 ± 24.3 | 56.7 ± 24.6 | 65.4 ± 27.4 | ||||
Perineurial invasion | Present | 54.0 ± 27.6 | 0.290 | 52.9 ± 25.6 | 0.356 | 73.9 ± 23.6 | 0.127 |
Absent | 47.9 ± 24.1 | 58.3 ± 25.0 | 64.4 ± 27.9 | ||||
Tumor necrosis | Present | 53.1 ± 25.7 | 0.276 | 66.4 ± 21.3 | 0.002* | 70.4 ± 25.6 | 0.320 |
Absent | 47.3 ± 24.7 | 50.7 ± 25.7 | 64.7 ± 27.9 | ||||
CIS at adjacent mucosa | Present | 55.2 ± 22.3 | 0.161 | 58.6 ± 24.1 | 0.658 | 66.9 ± 28.5 | 0.997 |
Absent | 47.2 ± 25.9 | 56.0 ± 25.7 | 66.9 ± 26.6 | ||||
HDGF-N | r = 0.131 | 0.204 | r = 0.280 | 0.006* | |||
HDGF-C | r = −0.022 | 0.831 | |||||