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Table 1 Correlation of HDGF, VEGF and clinicopathological data

From: Novel HDGF/HIF-1α/VEGF axis in oral cancer impacts disease prognosis

ParametersHDGF-NP valueHDGF-CP valueVEGFP value
GenderMale50.0 ± 24.70.36856.6 ± 25.10.65067.0 ± 27.40.815
Female36.6 ± 40.4 63.3 ± 30.6 63.3 ± 15.3 
Age (years) r = 0.1260.223r = 0.1120.281r = 0.040.970
Primary tumor (T)T1-T241.2 ± 21.60.004*53.6 ± 27.60.16661.02 ± 27.90.038*
T345.3 ± 24.1 54.7 ± 23.0 68.3 ± 28.4 
T459.2 ± 27.1 61.5 ± 22.4 73.6 ± 24.8 
Nodal status (N)N049.7 ± 22.60.92454.6 ± 26.80.81459.3 ± 23.60.021*
N150.3 ± 20.2 64.7 ± 24.9 67.7 ± 27.9 
N240.2 ± 28.9 55.9 ± 23.8 73.3 ± 28.3 
Extracapsular extension of metastatic nodesPresent54.7 ± 29.60.14958.7 ± 26.30.99677.3 ± 25.50.052
Absent44.9 ± 24.7 58.7 ± 23.3 63.7 ± 29.4 
Histological gradeW-D40.9 ± 25.10.013*61.9 ± 24.30.06158.1 ± 23.70.017*
M-D53.6 ± 22.9 57.6 ± 26.6 75.7 ± 24.4 
P-D59.1 ± 24.6 45.9 ± 21.9 68.8 ± 32.5 
Vascular invasionPresent55.2 ± 27.10.20557.1 ± 27.30.94871.7 ± 25.90.325
Absent47.7 ± 24.3 56.7 ± 24.6 65.4 ± 27.4 
Perineurial invasionPresent54.0 ± 27.60.29052.9 ± 25.60.35673.9 ± 23.60.127
Absent47.9 ± 24.1 58.3 ± 25.0 64.4 ± 27.9 
Tumor necrosisPresent53.1 ± 25.70.27666.4 ± 21.30.002*70.4 ± 25.60.320
Absent47.3 ± 24.7 50.7 ± 25.7 64.7 ± 27.9 
CIS at adjacent mucosaPresent55.2 ± 22.30.16158.6 ± 24.10.65866.9 ± 28.50.997
Absent47.2 ± 25.9 56.0 ± 25.7 66.9 ± 26.6 
HDGF-N   r = 0.1310.204r = 0.2800.006*
HDGF-C     r = −0.0220.831
  1. W-D, Well differentiated; M-D, Moderately differentiated; P-D, Poorly differentiated; CIS, Carcinoma in situ; HDGF-N, Nuclear expression of hepatoma-derived growth factor; HDGF-C, Cytoplasmic expression of hepatoma-derived growth factor; VEGF, Vascular endothelial growth factor; *, Statistical significance; All values are presented as mean ± SD. The correlation analyses were evaluated using the X2 test, t-test, and ANOVA as appropriate