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Fig. 1 | BMC Cancer

Fig. 1

From: Novel HDGF/HIF-1α/VEGF axis in oral cancer impacts disease prognosis

Fig. 1

Correlation of HDGF and VEGF expression in oral cancer. a, b Correlation between HDGF and VEGF mRNA levels in oral cancer and head and neck cancer patients obtained by analysis of data from TCGA. HDGF expression is positively correlated with VEGFA expression in human head and neck squamous cell carcinoma tissues, including oral cancer. c Tissue microarray analysis of the correlation between HDGF and VEGF expression in oral cancer patients. The photographs were from two representative oral cancer patients. Case 1 (pT2N0M0, stage II) exhibited low-expression HDGF and VEGF immunostaining, whereas Case 2 (pT3N2M0, stage III) showed high-expression staining of both HDGF and VEGF. Scale bars, 20 μm. d Immunofluorescence staining of oral cancer patients. The fluorescent color of HDGF was Green (AlexaFluor 488); VEGF was red (AlexaFluor 546); nuclei were stained with blue color (DAPI). Case 3 (pT1N0M0, stage I) exhibited both high-intensity staining of HDGF and VEGF, whereas Case 4 (pT2N0M0, stage II) showed intermediate-intensity HDGF and VEGF immunofluorescence staining, and Case 5 (pT1N0M0, stage II) showed low-intensity staining of HDGF and VEGF. Scale bars, 20 μm

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