Lesion | Clinical observations | Dermoscopic features | RCM findings | Pathology |
---|---|---|---|---|
Lesion 1 (Fig. 2a-d) | Skin-colored, dome-shaped tumor | Structureless hypopigmented area; linear vessels at periphery | – | Junctional component: |
None | ||||
Dermal component: | ||||
Large atypical epithelioid cells (top) | ||||
Mature melanocytes (bottom) | ||||
Adipocyte metaplasia (focal) | ||||
Lack of pigmentation | ||||
Lack of inflammation | ||||
Lesion 2 (Fig. 2e-h) | Reddish-brown papule | Central structureless, light brown area; irregular eccentric globules | – | Junctional component: |
Few nests of typical melanocytes | ||||
Dermal component: | ||||
Large atypical epithelioid cells (top) | ||||
Mature melanocytes (bottom) | ||||
Adipocyte metaplasia (focal) | ||||
Moderate pigmentation | ||||
Lack of inflammation | ||||
Lesion 3 (Fig. 3) | Brown papule | Clustered brown globules (periphery); irregular pigmentation within a central light brown structureless area | Dense and regular dermal nests (periphery); Sparse, isolated round nucleated cells at dermal-epidermal junction; Nonhomogeneous dermal nests (center) | Junctional component: |
Irregular large nests of typical melanocytes (periphery). Center lacking nest formation. | ||||
Dermal component: | ||||
Large atypical epithelioid cells (top) | ||||
Mature melanocytes (bottom). | ||||
Adipocyte metaplasia (focal) | ||||
Lack of pigmentation | ||||
Lack of inflammation |