Skip to main content

Table 1 Characteristics of the BIMT lesions identified

From: BAP1 tumor predisposition syndrome case report: pathological and clinical aspects of BAP1-inactivated melanocytic tumors (BIMTs), including dermoscopy and confocal microscopy

Lesion

Clinical observations

Dermoscopic features

RCM findings

Pathology

Lesion 1 (Fig. 2a-d)

Skin-colored, dome-shaped tumor

Structureless hypopigmented area; linear vessels at periphery

Junctional component:

None

Dermal component:

Large atypical epithelioid cells (top)

Mature melanocytes (bottom)

Adipocyte metaplasia (focal)

Lack of pigmentation

Lack of inflammation

Lesion 2 (Fig. 2e-h)

Reddish-brown papule

Central structureless, light brown area; irregular eccentric globules

Junctional component:

Few nests of typical melanocytes

Dermal component:

Large atypical epithelioid cells (top)

Mature melanocytes (bottom)

Adipocyte metaplasia (focal)

Moderate pigmentation

Lack of inflammation

Lesion 3 (Fig. 3)

Brown papule

Clustered brown globules (periphery); irregular pigmentation within a central light brown structureless area

Dense and regular dermal nests (periphery); Sparse, isolated round nucleated cells at dermal-epidermal junction; Nonhomogeneous dermal nests (center)

Junctional component:

Irregular large nests of typical melanocytes (periphery). Center lacking nest formation.

Dermal component:

Large atypical epithelioid cells (top)

Mature melanocytes (bottom).

Adipocyte metaplasia (focal)

Lack of pigmentation

Lack of inflammation