Table 1 Patient characteristics and distribution of SLC39A6 rs1050631 genotypes
Variables | Patients N (%) | SLC39A6 rs1050631 genotype (N) | P* | Pdominant a | Padditive b | ||
|---|---|---|---|---|---|---|---|
TT(%) | CT(%) | CC(%) | |||||
Total | 512 | 20 (3.9) | 139 (27.1) | 353 (69.0) | |||
Age | 0.26 | 0.25 | 0.14 | ||||
< 60 | 235 (45.9) | 6 (1.2) | 61 (11.9) | 168 (32.8) | |||
≥ 60 | 277 (54.1) | 14 (2.7) | 78 (15.2) | 185 (36.1) | |||
Gender | 0.38 | 0.18 | 0.25 | ||||
Male | 383 (74.8) | 15 (2.9) | 110 (21.5) | 258 (50.4) | |||
Female | 129 (25.2) | 5 (1.0) | 29 (5.7) | 95 (18.5) | |||
Grade of differentiation | 0.85 | 0.93 | 0.86 | ||||
Well differentiated | 21 (4.1) | 1 (0.2) | 6 (1.2) | 14 (2.7) | |||
Moderately differentiated | 263 (51.4) | 9 (1.8) | 75 (14.6) | 179 (35.0) | |||
Poorly differentiated | 228 (44.5) | 10 (2.0) | 58 (11.3) | 160 (31.2) | |||
Gross findings | 0.79 | 0.96 | 0.81 | ||||
Apophysis | 35 (6.8) | 2 (0.4) | 9 (1.8) | 24 (4.7) | |||
Invasion | 477 (93.2) | 18 (3.5) | 130 (25.4) | 329 (64.3) | |||
Lauren classification | 0.65 | 0.45 | 0.22 | ||||
Intestinal type | 420 (82.1) | 18 (3.5) | 119 (23.2) | 283 (55.3) | |||
Diffuse type | 81 (15.8) | 2 (0.4) | 18 (3.5) | 61((11.9)) | |||
Uncertain type | 11 (2.1) | 0 (0) | 2 (0.4) | 9 (1.8) | |||
Tumor location | 0.32 | 0.38 | 0.42 | ||||
Upper third | 179 (35.0) | 4 (0.8) | 52 (10.2) | 123 (24.0) | |||
Middle third | 78 (15.2) | 4 (0.8) | 16 (3.1) | 58 (11.3) | |||
Lower third | 252 (49.2) | 12 (2.3) | 69 (13.5) | 171 (33.4) | |||
Total | 3 (0.6) | 0 (0) | 2 (0.4) | 1 (0.2) | |||
Tumor size | 0.99 | 0.88 | 0.92 | ||||
≥ 5 cm | 210 (41.0) | 8 (1.6) | 58 (11.3) | 144 (28.1) | |||
< 5 cm | 302 (59.0) | 12 (2.3) | 81 (15.8) | 209 (40.8) | |||
Survival | 0.002 | < 0.001 | < 0.001 | ||||
Alive | 182 (35.5) | 4 (0.4) | 35 (6.8) | 143 (27.9) | |||
Dead | 330 (64.5) | 16 (3.1) | 104 (20.3) | 210 (41.0) | |||
Recurrence | 0.004 | < 0.001 | < 0.001 | ||||
Yes | 334 (65.2) | 16 (3.1) | 104 (20.3) | 214 (41.8) | |||
No | 178 (34.8) | 4 (0.8) | 35 (6.8) | 139 (27.1) | |||
Distant metastasis | 0.43 | 0.87 | 0.81 | ||||
Yes | 63 (12.3) | 4 (0.8) | 15 (2.9) | 44 (8.6) | |||
No | 449 (87.7) | 16 (3.1) | 124 (24.2) | 309 (60.4) | |||
Lymph node metastasis | 0.12 | 0.21 | 0.08 | ||||
Yes | 398 (77.7) | 19 (3.7) | 110 (21.5) | 269 (52.5) | |||
No | 114 (22.3) | 1 (0.2) | 29 (5.7) | 84 (16.4) | |||
Chemotherapy | |||||||
Yes | 329 (64.3) | 13 (2.5) | 93 (18.2) | 223 (43.6) | 0.61 | 0.78 | 0.69 |
No | 183 (35.7) | 7 (1.4) | 46 (9.0) | 130 (25.4) | |||