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Fig. 3 | BMC Cancer

Fig. 3

From: Ionizing radiation increases the endothelial permeability and the transendothelial migration of tumor cells through ADAM10-activation and subsequent degradation of VE-cadherin

Fig. 3

Influence of ionizing radiation on the expression of VE-cadherin in endothelial cells. a) Quantitative immunoblot analysis of VE-cadherin expression 24 h after irradiation (n = 4). Data were normalized to β-actin levels and are shown relative to the non-irradiated control (0 Gy). b) Quantitative immunoblot analysis of a 35-kDa proteolytic VE-cadherin fragment 24 h after irradiation (C, n = 3; data as described in a). c) Quantification of VE-cadherin mRNA expression levels 24 h after irradiation (n = 3; ΔΔCT method with GAPDH as reference target; data is shown relative to the non-irradiated control). Exemplary immunoblots are shown in A and B. Data shown are means ± standard deviations. Statistics: t-test, *p < 0.05, **p < 0.01, ***p < 0.001

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BMC Cancer

ISSN: 1471-2407

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