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Fig. 2 | BMC Cancer

Fig. 2

From: Ionizing radiation increases the endothelial permeability and the transendothelial migration of tumor cells through ADAM10-activation and subsequent degradation of VE-cadherin

Fig. 2

Effect of ionizing radiation on the expression levels of ADAM10 and ADAM17 in endothelial cells. a and b) ADAM10 (A) and ADAM17 (B) mRNA levels 24 h after irradiation with 2 Gy or 4 Gy, relative to those in non-irradiated controls (ΔΔCT-method). c-d) Quantitative immunoblot analysis. ADAM10 (C) and ADAM17 (D) protein levels (normalized to β-actin) measured 24 h after irradiation are shown relative to those in non-irradiated controls. e) Exemplary immunoblot showing protein bands 12 h and 24 h after irradiation. Values shown are means (n ≥ 3) and standard deviations. Statistics: t-test, *p < 0.05, **p < 0.01, *p < 0.001

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BMC Cancer

ISSN: 1471-2407

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