Fig. 1
From: Cooperation of Dnmt3a R878H with Nras G12D promotes leukemogenesis in knock-in mice: a pilot study
DKI mice show significantly shortened survival time. a Experimental scheme of the generation of conditional DKI mice. b Genotype identification of DKI mice (Mx1-Cre; Dnmt3aR878H/+; NrasG12D/+), Dnmt3aR878H/+ mice (Mx1-Cre; Dnmt3aR878H/+), NrasG12D/+ mice (Mx1-Cre; NrasG12D/+), and WT control. PCR was carried out by using the primers were listed in Additional file 1: Table S1. c Count of WBCs of mice with the indicated genotype after pIpC induction (n = 10 for each group). d Kaplan–Meier survival analysis of four groups of mice. (n = 8 for each group). ***P < 0.001