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Fig. 6 | BMC Cancer

Fig. 6

From: Autophagy inhibition enhances Matrine derivative MASM induced apoptosis in cancer cells via a mechanism involving reactive oxygen species-mediated PI3K/Akt/mTOR and Erk/p38 signaling

Fig. 6

ROS scavenger NAC reversed the effects of MASM in MDA-MB-231. Administration of NAC (5 mM) with MASM could rescue the decrease in cell number as observed under a light microscope (a), cell viability as determined by MTT assay (b), rescue of cells from apoptosis as detected by Annexin V/PI double staining (c) and western blot showing the inhibitory effect of NAC on the MASM-induced activation of Erk1/2 and p38 and the accumulation of LC3-II (d). Bar graphs represent the mean ± SD of 3 independent experiments. *P < 0.05, ** P < 0.01

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