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Fig. 5 | BMC Cancer

Fig. 5

From: Autophagy inhibition enhances Matrine derivative MASM induced apoptosis in cancer cells via a mechanism involving reactive oxygen species-mediated PI3K/Akt/mTOR and Erk/p38 signaling

Fig. 5

Inhibition of MASM induced autophagy enhanced apoptosis in MDA-MB-231. A. The apoptosis in MDA-MB-231 induced by MASM (60 μg/ml) in the presence or absence of autophagy inhibitor CQ (10 μM), LY294002 (10 μM), or Wortmaninn (1 μM) was analyzed by flow cytometry using Annexin V/PI double staining. B. The apoptosis in MDA-MB-231 induced by MASM in the presence or absence of PD184352 (2 μM) or SB203580 (10 μM), was analyzed by flow cytometry using Annexin V/PI double staining. Results are shown as the mean ± SD of 3 independent experiments. *P < 0.05, **P < 0.01

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