Fig. 1

MASM induced a dose- and time-dependent inhibitory effect on cell viability. a Chemical structure of matrine and its derivate MASM; b Viability of cells follwoing exposure to different concentrations of MASM for 8 h,12 h and 24 h. Cell viability was determined using MTT assay; c The effect of MASM treatment for 24 h on LDH release. Data are representative of at least three independent experiments