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Table 2 Multivariate-adjusted Cox proportional hazard regression models predicting OS and RFS classified by AJCC 8th edition N stage, LNR, and LODDS

From: Lymph node ratio as valuable predictor in pancreatic cancer treated with R0 resection and adjuvant treatment

 

Number of patients

OS

RFS

Median OS, months

HR (95% CI) a

p

AIC

Bootstrap-corrected C index

Median RFS, months

HR (95% CI) a

p

AIC

Bootstrap-corrected C index

pN (AJCC 8th)

 0

150

50.8

1

< 0.001

2003.0

0.57

23.5

1

< 0.001

2274.3

0.57

 1

135

27.0

1.58 (1.14-2.19)

15.0

1.34 (0.98-1.83)

 2

66

22.5

2.00 (1.36-2.95)

10.1

2.01 (1.38-2.92)

LNR

 0

150

50.8

1

< 0.001

2005.9

0.65

23.5

1

0.001

2278.4

0.63

  > 0 to ≤0.2

141

26.3

1.62 (1.17-2.23)

13.5

1.39 (1.02-1.88)

  > 0.2 to ≤0.4

23

21.5

1.66 (0.90-3.01)

11.0

1.80 (1.02-3.18)

  > 0.4

37

21.4

2.05 (1.31-3.20)

9.2

1.90 (1.23-2.96)

LODDS

 Quantile 1

89

48.8

1

0.002

2008.8

0.64

20.6

1

0.009

2277.5

0.63

 Quantile 2

91

34.8

1.26 (0.84-1.91)

17.3

1.17 (0.79-1.72)

 Quantile 3

85

27.4

1.46 (0.97-2.20)

15.4

1.24 (0.84-1.84)

 Quantile 4

86

22.0

1.90 (1.25-2.87)

10.1

1.78 (1.21-2.62)

  1. OS overall survival, RFS recurrence-free survival, AIC akaike information criterion, AJCC American Joint Committee on Cancer, LNR lymph-node ratio, LODDS log odds of positive lymph nodes, CA 19-9 carbohydrate antigen 19-9
  2. a HR adjusted with the histologic grade, lymphovascular invasion, perineural invasion, pathologic T stage, and preoperative CA19-9 ≥ 100 U/mL