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Table 4 Cox proportional hazards for PSA recurrence-free survival after prostatectomy of established preoperative prognostic parameter and PTPN12 expression

From: High-level expression of protein tyrosine phosphatase non-receptor 12 is a strong and independent predictor of poor prognosis in prostate cancer

Variable Univariable analysis Multivariable analysis
Gleason grade biopsy
  ≥ 4 + 4 vs. ≤3 + 3 6.01 (5.41–6.66) *** 4.21 (3.71–4.79) ***
Preoperative PSA-level (ng/μl)
  > 20 vs. < 4 5.12 (4.46–5.89) *** 3.14 (2.61–3.80) ***
cT-stage
 T2c vs. T1c 3.95 (3.24–4.76) *** 2.08 (1.66–2.58) ***
PTPN12 expression
 Strong vs. negative 1.85 (1.53–2.23) *** 1.71 (1.40–2.07) ***
 ERG negative subset 2.50 (1.82–3.35) *** 2.28 (1.65–3.09) ***
 ERG positive subset 1.51 (1.23–2.02) * 1.37 (1.01–1.85) *
  1. Confidence interval (95%) in brackets; asterisk indicate significance level: * p ≤ 0.05, ** p ≤ 0.001, *** p ≤ 0.0001; ERG ETS-related gene