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Table 2 PTPN12 staining results of the primary tumor and prostate cancer phenotype in all cancers

From: High-level expression of protein tyrosine phosphatase non-receptor 12 is a strong and independent predictor of poor prognosis in prostate cancer

Parameter N PTPN12 (%) P
Negative Weak Moderate Strong
All cancers 10,317 28.9 26.5 39.9 4.7  
Tumor stage < 0.0001
 pT2 6438 32.8 26.9 36.7 3.6
 pT3a 2385 24.2 25.7 44.6 5.5
 pT3b-pT4 1448 19.5 26.0 47.0 7.6
Gleason grade < 0.0001
  ≤ 3 + 3 1999 39.6 29.1 26.5 4.8
 3 + 4 5526 29.2 26.9 40.3 3.6
 3 + 4 Tert.5 444 26.4 26.1 44.4 3.2
 4 + 3 1030 20.8 26.0 47.0 6.2
 3 + 4 Tert.5 711 18.1 20.1 53.9 7.9
  ≥ 4 + 4 599 18.9 23.9 48.7 8.5
Quantitative Gleason grade < 0.0001
  ≤ 3 + 3 1971 39.7 29.1 26.3 4.8
 3 + 4 ≤ 5% 1305 33.4 27.2 36.2 3.2
 3 + 4 6–10% 1288 31.4 26.8 38.5 3.3
 3 + 4 11–20% 1059 28.0 25.1 44.2 2.6
 3 + 4 21–30% 600 25.0 26.7 42.7 5.7
 3 + 4 31–49% 483 26.5 25.5 43.9 4.1
 3 + 4 Tert.5 323 28.2 28.2 41.8 1.9
 4 + 3 50–60% 400 22.0 23.5 49.0 5.5
 4 + 3 61–80% 345 20.0 25.2 51.0 3.8
 4 + 3 > 80% 93 19.4 25.8 43.0 11.8
 4 + 3 Tert.5 518 20.5 21.6 53.3 4.6
  ≥ 4 + 4 406 20.4 25.6 48.3 5.7
Lymph node metastasis < 0.0001
 N0 6081 27.0 26.4 41.9 4.8
 N+ 718 17.4 22.0 53.5 7.1
Preoperative PSA level (ng/ml) 0.0158
  < 4 1222 25.1 26.1 42.7 6.1
 4–10 6084 29.4 26.8 39.6 4.2
 10–20 2146 29.7 25.4 39.7 5.1
  > 20 752 27.9 28.1 39.5 4.5
Surgical margin < 0.0001
 Negative 8120 30.0 26.5 39.3 4.2
 Positive 1982 24.3 27.0 42.2 6.4