Fig. 4

O-PLS prediction of vemurafenib sensitivity from different data forms. (a) Comparison of O-PLS model performances for training (7-fold cross validation, grey) and testing sets of cell lines (blue). Models were built on the RPPA dataset (RPPA), gene expression corresponding to RPPA proteins (RNAseq Subset), or gene expression of the MAPK signature (MAPK signature). Open symbols indicate melanoma cell lines, closed symbols indicate non-melanoma cell lines. (b, c) Comparison of univarate correlations of z-score normalized gene expression (blue), total protein expression (grey) and phospho-protein expression (yellow) of MEK1 (b) and HER3 (c) with IC₅₀ AUC