Fig. 3
O-PLS prediction of vemurafenib sensitivity from RPPA dataset. (a) Comparison of observed and predicted IC50 AUC values in training (7-fold cross validation) and testing set cell lines. Open symbols indicate melanoma cell lines, closed symbols indicate non-melanoma cell lines. (b) Scores plot of O-PLS model showing projection of training cells along first component t[1] and first orthogonal component to [1]. (c) Weights of proteins (VIP score > 1) along the predictive component. (d) Heatmap of z-score normalized proteins (VIP score > 1) whose weights correlate with resistant (left) and sensitive cell lines (right). Top heatmap indicates training set and bottom indicates testing set of cell lines in order of increasing IC50 AUC, with cell lines above the dotted line having IC50 AUC < 0.2