Fig. 1

Overview of dataset curation. (a) Intersection of number of cell lines represented in the MCLP RPPA level 4 dataset, CTRP vemurafenib response dataset, and CCLE database of BRAF-V600E mutated cells. (b) Pipeline of data curation and evaluation of machine learning models to predict vemurafenib response in BRAF-V600E cell lines. (c) Heatmap illustrating z-score normalized expression of 232 proteins used in model evaluation. Top heatmap indicates training set and bottom indicates testing set of cell lines in order of increasing IC₅₀ AUC, with cell lines above the dotted line having IC₅₀ AUC < 0.2