Skip to main content

Table 1 Characteristics of the primary studies included in the meta-analysis

From: Tubal ligation and endometrial Cancer risk: a global systematic review and meta-analysis

First author

DOP

SS

Design

Country

Population

Study quality*

# of cases in TL+

# of TL+

# of cases in TL-

# of TL-

TES

ES

UL

LL

AES

UL

LL

Adjusted for:

Castellsague X 14

1996

3634

Case control

USA

20 to 54 years

High

53

671

383

2963

OR

0.58

0.43

0.78

0.87

0.63

1.2

Age and Parity

Lacey JV Jr. 16

2000

701

Case control

USA

20 to 74 years

High

47

87

357

614

OR

0.9

0.6

1.4

1.4

0.8

2.3

Age, parity, and OC usage

Kjaer SK 17

2004

65,232

Cohort

Denmark

Women who had a tubal sterilization (1977–1993)

High

30

65,232

–

–

SIR

0.7

0.5

1

–

–

–

–

Rosenblatt KA 15

1997

1454

Case control

Seven countries

Older than 15

Moderate

35

377

101

1077

OR

–

–

–

1.26

0.79

2

Parity and age, hospital and date of diagnosis

Wernli KJ 11

2006

259,640

Cohort

China

Women employed in the textile industry

Moderate

59

–

147

–

HR

–

–

–

1.1

0.79

1.56

Age at baseline and reproductive category

Nagle CM 6

2008

1650

Case control

Australia

Cancer registries

Moderate

19

425

404

1225

OR

–

–

–

0.4

0.3

0.7

Age, education, parity and hormone contraceptive use

Iversen L 18

2007

5602

Cohort

United Kingdom

Women who were using oral contraceptives

High

1

2801

4

2801

–

–

–

–

–

–

–

–

Gaitskell K 10

2016

1,278,783

Cohort

United Kingdom

UK women

High

2018

206,233

8571

767,251

RR

–

–

–

0.98

0.93

1.03

Age, region, socioeconomic status, parity, age at first birth, hysterectomy, smoking, alcohol intake, physical activity, body mass index, and use of the oral, contraceptive pill or menopausal hormones

Winer I 9

2016

76,483

Cohort

USA

50 to 79 years, postmenopausal

High

192

14,499

945

61,984

HR

0.87

0.75

1.05

0.9

0.76

1.07

Age stratum at randomization and region

Falconer H 2

2018

5,385,186

Cohort

Switzerland

Swedish women

High

281

80,765

35,430

5,304,421

HR

–

–

–

0.73

0.65

0.83

Age, parity, calendar time and education status

  1. DOP Date of publication, SS Sample size, TL Tubal ligation, TES Type of reported effect size, ES Effect size, UL Upper limit, LL Lower limit, AES Adjusted effect size, OR odds ratio, SIR Standardized incidence ratio, RR Risk ratio, HR Hazard ratio, OC Oral contraception
  2. *Based on the Newcastle-Otawa scale