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Table 1 Characteristics of the primary studies included in the meta-analysis

From: Tubal ligation and endometrial Cancer risk: a global systematic review and meta-analysis

First author DOP SS Design Country Population Study quality* # of cases in TL+ # of TL+ # of cases in TL- # of TL- TES ES UL LL AES UL LL Adjusted for:
Castellsague X 14 1996 3634 Case control USA 20 to 54 years High 53 671 383 2963 OR 0.58 0.43 0.78 0.87 0.63 1.2 Age and Parity
Lacey JV Jr. 16 2000 701 Case control USA 20 to 74 years High 47 87 357 614 OR 0.9 0.6 1.4 1.4 0.8 2.3 Age, parity, and OC usage
Kjaer SK 17 2004 65,232 Cohort Denmark Women who had a tubal sterilization (1977–1993) High 30 65,232 SIR 0.7 0.5 1
Rosenblatt KA 15 1997 1454 Case control Seven countries Older than 15 Moderate 35 377 101 1077 OR 1.26 0.79 2 Parity and age, hospital and date of diagnosis
Wernli KJ 11 2006 259,640 Cohort China Women employed in the textile industry Moderate 59 147 HR 1.1 0.79 1.56 Age at baseline and reproductive category
Nagle CM 6 2008 1650 Case control Australia Cancer registries Moderate 19 425 404 1225 OR 0.4 0.3 0.7 Age, education, parity and hormone contraceptive use
Iversen L 18 2007 5602 Cohort United Kingdom Women who were using oral contraceptives High 1 2801 4 2801
Gaitskell K 10 2016 1,278,783 Cohort United Kingdom UK women High 2018 206,233 8571 767,251 RR 0.98 0.93 1.03 Age, region, socioeconomic status, parity, age at first birth, hysterectomy, smoking, alcohol intake, physical activity, body mass index, and use of the oral, contraceptive pill or menopausal hormones
Winer I 9 2016 76,483 Cohort USA 50 to 79 years, postmenopausal High 192 14,499 945 61,984 HR 0.87 0.75 1.05 0.9 0.76 1.07 Age stratum at randomization and region
Falconer H 2 2018 5,385,186 Cohort Switzerland Swedish women High 281 80,765 35,430 5,304,421 HR 0.73 0.65 0.83 Age, parity, calendar time and education status
  1. DOP Date of publication, SS Sample size, TL Tubal ligation, TES Type of reported effect size, ES Effect size, UL Upper limit, LL Lower limit, AES Adjusted effect size, OR odds ratio, SIR Standardized incidence ratio, RR Risk ratio, HR Hazard ratio, OC Oral contraception
  2. *Based on the Newcastle-Otawa scale
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