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Fig. 4 | BMC Cancer

Fig. 4

From: A novel Bcl-2 inhibitor, BM-1197, induces apoptosis in malignant lymphoma cells through the endogenous apoptotic pathway

Fig. 4

Deregulated the expression of Mcl-1 enhances the activity of BM-1197. a. Western blot confirms Mcl-1 knockdown in OCI-ly8 cells co-transfected with targeting or non-targeting (NT) siRNA. b. Knockdown of Mcl-1 enhances OCI-ly8 cells to BM-1197 treatment. c. BM-1197 induces more apoptosis in Mcl-1 knockdown OCI-ly8 cells. d. BM-1197 combined with BEZ235 and ADM can synergistically induce more significant apoptosis detected by flow cytometry. e. The expression change of apoptotic proteins and Mcl-1 in OCI-ly8 cells treated with BM-1197, BEZ235, ADM or co-treatment of above drugs

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BMC Cancer

ISSN: 1471-2407

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