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Fig. 3 | BMC Cancer

Fig. 3

From: A novel Bcl-2 inhibitor, BM-1197, induces apoptosis in malignant lymphoma cells through the endogenous apoptotic pathway

Fig. 3

BM-1197 induces apoptosis in a mitochondrial pathway. a. Caspase 3 activity in OCI-ly8 cells were measured 24 h after adding BM-1197 and were plotted relative to the DMSO control. b. Caspase 3 activity in OCI-ly8 cells were measured in indicated time points after adding BM-1197 and ere plotted relative to the DMSO control. c. Caspase 9 activity in OCI-ly8 cells was measured 24 h after treated with BM-1197 and was plotted relative to the DMSO control. d. Caspase 9 activity in OCI-ly8 cells was measured in indicated time points after adding BM-1197 and was plotted relative to the DMSO control. e. Cytochrome c (Cyt. c) expression in OCI-LY8 mitochondrial and cytosolic fractions were determined by western blot in indicated time points after adding BM-1197. COX IV and GAPDH serve as protein loading controls for the mitochondria and cytosol, respectively. f. Quantification of Cytochrome c (Cyt. c) abundance in OCI-LY8 mitochondrial and cytosolic fractions

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BMC Cancer

ISSN: 1471-2407

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