Variables | Univariable Cox | Multivariable Cox | ||
---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | |
Age (per 1 SD) | 1.05 (1.03–1.06) | <0.001 | 1.05 (1.03–1.07) | <0.001 |
Sex | ||||
 Female | Ref. |  |  |  |
 Male | 1.17 (1.06–1.29) | 0.003 | 1.14 (1.00–1.29) | 0.046 |
Race | Â | 0.20 | Â | Â |
 White | Ref. |  | – |  |
 Black | 1.05 (0.85–1.30) | 0.63 | – |  |
 Asian | 0.78 (0.58–1.04) | 0.09 | – |  |
CDCI Score | Â | <0.001 | Â | <0.001 |
 0 | Ref. |  | Ref. |  |
 1 | 1.28 (1.15–1.43) | <0.001 | 1.31 (1.14–1.51) | <0.001 |
 ≥ 2 | 1.77 (1.52–2.06) | <0.001 | 1.72 (1.41–2.08) | <0.001 |
Tumor size | Â | <0.001 | Â | <0.001 |
 ≤ 2 cm | Ref. |  | Ref. |  |
 2-4 cm | 1.51 (1.31–1.75) | <0.001 | 1.23 (1.03–1.47) | 0.02 |
 4-6 cm | 1.93 (1.65–2.26) | <0.001 | 1.34 (1.10–1.64) | 0.004 |
 >6 cm | 2.19 (1.85–2.59) | <0.001 | 1.36 (1.10–1.68) | 0.004 |
Differentiation grade | Â | <0.001 | Â | 0.005 |
 Well | Ref. |  | Ref. |  |
 Moderately | 1.36 (1.11–1.67) | 0.003 | 1.01 (0.78–1.31) | 0.94 |
 Poorly | 1.94 (1.59–2.37) | <0.001 | 1.27 (0.98–1.65) | 0.07 |
 Undifferentiated | 1.74 (1.19–2.56) | 0.005 | 1.18 (0.74–1.87) | 0.50 |
Analytic TNM stage | Â | <0.001 | Â | <0.001 |
 Stage 0-I | Ref. |  | Ref. |  |
 Stage II | 1.71 (1.50–1.94) | <0.001 | 1.36 (1.15–1.61) | <0.001 |
 Stage III | 2.62 (2.33–2.95) | <0.001 | 2.24 (1.89–2.65) | <0.001 |
If surgery | ||||
 No | Ref. |  | Ref. |  |
 Yes | 0.50 (0.44–0.57) | <0.001 | 0.66 (0.51–0.86) | 0.002 |
If chemotherapy | ||||
 No | Ref. |  | – |  |
 Yes | 0.90 (0.80–1.01) | 0.08 | – |  |
If radiotherapy | ||||
 No | Ref. |  | – |  |
 Yes | 1.00 (0.88–1.13) | 0.98 | – |  |