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Table 1 Cox proportional hazards model for overall survival in the elderly patients with resectable proximal gastric carcinoma from NCDB database

From: Optimal treatment for elderly patients with resectable proximal gastric carcinoma: a real world study based on National Cancer Database

Variables

Univariable Cox

Multivariable Cox

HR (95% CI)

P

HR (95% CI)

P

Age (per 1 SD)

1.05 (1.03–1.06)

<0.001

1.05 (1.03–1.07)

<0.001

Sex

 Female

Ref.

   

 Male

1.17 (1.06–1.29)

0.003

1.14 (1.00–1.29)

0.046

Race

 

0.20

  

 White

Ref.

 

–

 

 Black

1.05 (0.85–1.30)

0.63

–

 

 Asian

0.78 (0.58–1.04)

0.09

–

 

CDCI Score

 

<0.001

 

<0.001

 0

Ref.

 

Ref.

 

 1

1.28 (1.15–1.43)

<0.001

1.31 (1.14–1.51)

<0.001

 ≥ 2

1.77 (1.52–2.06)

<0.001

1.72 (1.41–2.08)

<0.001

Tumor size

 

<0.001

 

<0.001

 ≤ 2 cm

Ref.

 

Ref.

 

 2-4 cm

1.51 (1.31–1.75)

<0.001

1.23 (1.03–1.47)

0.02

 4-6 cm

1.93 (1.65–2.26)

<0.001

1.34 (1.10–1.64)

0.004

 >6 cm

2.19 (1.85–2.59)

<0.001

1.36 (1.10–1.68)

0.004

Differentiation grade

 

<0.001

 

0.005

 Well

Ref.

 

Ref.

 

 Moderately

1.36 (1.11–1.67)

0.003

1.01 (0.78–1.31)

0.94

 Poorly

1.94 (1.59–2.37)

<0.001

1.27 (0.98–1.65)

0.07

 Undifferentiated

1.74 (1.19–2.56)

0.005

1.18 (0.74–1.87)

0.50

Analytic TNM stage

 

<0.001

 

<0.001

 Stage 0-I

Ref.

 

Ref.

 

 Stage II

1.71 (1.50–1.94)

<0.001

1.36 (1.15–1.61)

<0.001

 Stage III

2.62 (2.33–2.95)

<0.001

2.24 (1.89–2.65)

<0.001

If surgery

 No

Ref.

 

Ref.

 

 Yes

0.50 (0.44–0.57)

<0.001

0.66 (0.51–0.86)

0.002

If chemotherapy

 No

Ref.

 

–

 

 Yes

0.90 (0.80–1.01)

0.08

–

 

If radiotherapy

 No

Ref.

 

–

 

 Yes

1.00 (0.88–1.13)

0.98

–

 
  1. NCDB National Cancer Database, HR Hazard ratio, CI Confidence interval, CDCI Charlson-Deyo Comorbidity Index. TNM was based on the T, N, and M elements defined by the American Joint Committee on Cancer (AJCC), the 7th edition. Analytic TNM Stage Group is assigned the value of reported Pathologic Stage Group. Clinical Stage Group is used if pathologic stage is not reported