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Table 1 Relationship of FGFR3 with different clinicopathologic parameters of melanoma patients

From: FGFR3 promotes the growth and malignancy of melanoma by influencing EMT and the phosphorylation of ERK, AKT, and EGFR

Parameters FGFR3 expression
n Low High P
Age
 ≤ 60 29 19 10 NS
 > 60 13 7 6  
Gender
 Male 25 17 8 NS
 Female 17 9 8  
Location
 Head/neck 2 1 1 NS
 Trunk 29 18 11  
 Extremities 8 5 3  
 Feet 3 2 1  
Breslow thickness
 1.01–2.00 14 12 2 0.0119
 2.01–4.00 15 6 9  
  > 4.00 13 8 5  
Clark Classification
 I-II 9 6 3 NS
 III-IV 33 20 13  
Ulceration
 Yes 20 10 10 NS
 No 22 16 6  
Nodular
 Yes 17 9 8 NS
 No 25 17 8  
SLN status
 Not involved 27 21 6 0.0045
 Involved 15 5 10  
  1. Note: NS No significance, SNL Sentinel lymph node