Skip to main content
Fig. 1 | BMC Cancer

Fig. 1

From: Ectopic expression of BIRC5-targeting miR-101-3p overcomes bone marrow stroma-mediated drug resistance in multiple myeloma cells

Fig. 1

BMSCs modulate an array of mRNAs in MM cells. RPMI-8226, U266 and MM.1S cells were co-cultured with HS-5 cells in the presence of 5 nM BTZ for 24 h. MM cells were isolated using magnetic bead assay (EasySep), cDNAs were synthesized and applied to pathway-(apoptosis, proliferation, and survival)-focused mRNA qPCR array. The graphs for RPMI-8226 and MM.1S cells are the re-analysis of selected genes from an array of 84 (Additional file 1: Figure S1, clusterogram). The same graph for U266 cell line is in the supplementary (Additional file 2: Figure S2). The graphs show the fold changes of transcripts in MM cells co-cultured with HS-5 cells compared to MM cells cultured alone, details in the M&M

Back to article page