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Fig. 2 | BMC Cancer

Fig. 2

From: Screening antiproliferative drug for breast cancer from bisbenzylisoquinoline alkaloid tetrandrine and fangchinoline derivatives by targeting BLM helicase

Fig. 2

Effects of HJNO and MMC on the DNA binding of BLM642–1290 helicase. a Effects of HJNO on fluorescence anisotrophy of dsDNA or ssDNA (21 nt) and complexes of BLM642–1290 binding dsDNA or ssDNA (21 nt). b Effects of HJNO on the dsDNA or ssDNA (21 nt) binding of BLM642–1290 helicase. c Effects of MMC on fluorescence anisotrophy of dsDNA or ssDNA (21 nt) and complexes of BLM 642–1290 binding dsDNA or ssDNA (21 nt). d Effects of MMC on the dsDNA or ssDNA (21 nt) binding of BLM 642–1290 helicase. e, f Effects of HJNO on complexes of BLM642–1290 binding dsDNA detected by EMSA and statistic results. g, h Effects of MMC on complexes of BLM 642–1290 binding dsDNA detected by EMSA and statistic results. Note: A0 is the fluorescence anisotrophy of DNA binding small molecular substances. A1 is the fluorescence anisotrophy of complexes which is formed by BLM binding DNA and small molecules

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