Global differences in the prevalence of the CpG island methylator phenotype of colorectal cancer

BMC Cancer

Table 1 Metaregression analysis of comparison of CIMP-H prevalence across continents. Using North America as the reference group, pooled prevalence using unadjusted and adjusted estimates are shown

	N Studies	N (Total sample size)	N (Total CIMP-H)	Mean CIMP-H prevalence	95% confidence interval	P-Value for unadjusted metaregression	P-Value for adjusted metaregression
North America	19	13,138	2162	27%	23–31%	Ref	Ref
Asia	30	6628	1113	22%	18–26%	0.24	0.35
Australia	12	4315	618	21%	14–28%	0.19	0.35
Europe	37	7926	1583	21%	18–24%	0.15	0.31
South America	2	159	40	25%	18–31%	0.66	0.90

ISSN: 1471-2407