Table 4 Cox proportional hazards regression of all patients for intracranial progression
Variables | Hazard ratio (95% CI) | p value |
|---|---|---|
Age > 65 | 1.12 (0.771 to 1.615) | 0.561 |
Sex (male) | 0.93 (0.617 to 1.395) | 0.718 |
Smoking | 1.06 (0.594 to 1.900) | 0.838 |
EGFR mutation | ||
 L858R only | Reference |  |
 Del 19 only | 0.94 (0.643 to 1.363) | 0.729 |
 Uncommon mutation | 2.26 (0.802 to 6.341) | 0.123 |
 Complex mutations | 2.95 (1.050 to 8.264) | 0.040 |
Initial brain metastases number ≥ 3 | 1.16 (0.800 to 1.685) | 0.432 |
RT to brain before 1st PD | 0.80 (0.535 to 1.191) | 0.270 |
Brain tumor excision | 0.91 (0.608 to 1.362) | 0.209 |
TKI | ||
 Gefitinib | Reference |  |
 Erlotinib | 0.85 (0.568 to 1.283) | 0.447 |
 Afatinib | 1.00 (0.602 to 1.662) | 1.000 |