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Table 2 Mian characteristics of the meta-analysis for prognosis and clinicopathologic association of circRNAs in CRC

From: A pair-wise meta-analysis highlights circular RNAs as potential biomarkers for colorectal cancer

Study Locale Case size TNM Stage (I, II, III, IV) Sample Type CircRNA signature Expression status/ Biological function Survival indicator Follow-up time HR & 95% CI Extraction Assessed clinicopathologic association
High Low
Wang F 2018 [10] China 23 23 I + II: 17, III + IV: 29 Tissue hsa_circ_0014717 Down-regulated/ Tumor suppressor OS 1 to 3 month intervals Indirectly Yes
Hsiao KY 2017 [12] China Total: 131 Unclear Tissue circCCDC66 Up-regulated/ Tumor promotor OS Unclear Indirectly Yes
Li J 2018 [14] China 50 51 21, 32, 40, 8 Tissue hsa_circ_0000711 Down-regulated/ Tumor suppressor OS Medain:39 month Directly Yes
Zeng K 2018 [15] China 89 89 I + II: 121, III + IV: 57 Tissue circHIPK3 Up-regulated/ Tumor promotor OS Unclear Directly No
Yuan Y 2018 [17] China 15 17 Unclear Tissue circ_0026344 Down-regulated/ Tumor suppressor OS Unclear Indirectly No
Fang G 2018 [18] China 24 20 Unclear Tissue circRNA_100290 Up-regulated/ Tumor promotor OS Unclear Indirectly No
Weng W 2017 [21] China 76 77 19, 84, 47, 3 Tissue ciRS-7 Up-regulated/ Tumor promotor OS Unclear Directly No
   89 76 26, 52, 49, 38 Tissue ciRS-7 Up-regulated/ Tumor promotor OS Unclear Directly No
  1. OS overall survival, HR hazard ratio