Table 2 Mian characteristics of the meta-analysis for prognosis and clinicopathologic association of circRNAs in CRC
From: A pair-wise meta-analysis highlights circular RNAs as potential biomarkers for colorectal cancer
Study | Locale | Case size | TNM Stage (I, II, III, IV) | Sample Type | CircRNA signature | Expression status/ Biological function | Survival indicator | Follow-up time | HR & 95% CI Extraction | Assessed clinicopathologic association | |
|---|---|---|---|---|---|---|---|---|---|---|---|
High | Low | ||||||||||
Wang F 2018 [10] | China | 23 | 23 | I + II: 17, III + IV: 29 | Tissue | hsa_circ_0014717 | Down-regulated/ Tumor suppressor | OS | 1 to 3 month intervals | Indirectly | Yes |
Hsiao KY 2017 [12] | China | Total: 131 | Unclear | Tissue | circCCDC66 | Up-regulated/ Tumor promotor | OS | Unclear | Indirectly | Yes | |
Li J 2018 [14] | China | 50 | 51 | 21, 32, 40, 8 | Tissue | hsa_circ_0000711 | Down-regulated/ Tumor suppressor | OS | Medain:39 month | Directly | Yes |
Zeng K 2018 [15] | China | 89 | 89 | I + II: 121, III + IV: 57 | Tissue | circHIPK3 | Up-regulated/ Tumor promotor | OS | Unclear | Directly | No |
Yuan Y 2018 [17] | China | 15 | 17 | Unclear | Tissue | circ_0026344 | Down-regulated/ Tumor suppressor | OS | Unclear | Indirectly | No |
Fang G 2018 [18] | China | 24 | 20 | Unclear | Tissue | circRNA_100290 | Up-regulated/ Tumor promotor | OS | Unclear | Indirectly | No |
Weng W 2017 [21] | China | 76 | 77 | 19, 84, 47, 3 | Tissue | ciRS-7 | Up-regulated/ Tumor promotor | OS | Unclear | Directly | No |
89 | 76 | 26, 52, 49, 38 | Tissue | ciRS-7 | Up-regulated/ Tumor promotor | OS | Unclear | Directly | No | ||