From: A pair-wise meta-analysis highlights circular RNAs as potential biomarkers for colorectal cancer
Study | Locale | Patient number | Control number | Control type | Sample Type | CircRNA signature | Expression status/Biological function | Method | Cut-Off Value | Reference gene | AUC | Assessed clinicopathologic association |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Wang J 2018 [9] | Chinese | 102 | 102 | Adjacent noncancerous tissues | Tissue | hsa_circ_0000567 | Down-regulated/ Tumor suppressor | qRT-PCR/2 − ΔΔCt | 0.4714 | 18S rRNA, GAPDH | 0.8653 | Yes |
Wang F 2018 [10] | Chinese | 46 | 46 | Pair-matched adjacent normal tissues | Tissue | hsa_circ_0014717 | Down-regulated/ Tumor suppressor | qRT-PCR/2 − ΔΔCt | / | GAPDH | 0.683 | Yes |
Wang X 2015 [11] | Chinese | 62 | 62 | Adjacent normal mucosa | Tissue | hsa_circ_001988 | Down-regulated/ Tumor suppressor | qRT-PCR/ΔCt | 6.04 | GAPDH | 0.788 | Yes |
Hsiao KY 2017 [12] | 131 | 76 | Paired noncancerous counterparts | Tissue | circCCDC66 | Up-regulated/ Tumor promotor | RNA sequencing | / | GAPDH | 0.88 | Yes | |
Zhang P 2017 [13] | Chinese | 170 | 170 | Normal colorectal tissue samples | Tissue | hsa_circRNA_104700 | Down-regulated/ Tumor suppressor | qRT-PCR/Ct | 10.753 | GAPDH | 0.699 | Yes |
hsa_circRNA_103809 | Down-regulated/ Tumor suppressor | qRT-PCR/Ct | 13.9 | GAPDH | 0.616 | Yes | ||||||
Li J 2018 [14] | Chinese | 101 | 101 | Paired noncancerous counterparts | Tissue | hsa_circ_0000711 | Down-regulated/ Tumor suppressor | qRT-PCR/ΔCt | ΔCt: 3.37 | GAPDH | 0.81 | Yes |
Ji WX 2018 [16] | Chinese | 64 | 64 | Paired noncancerous counterparts | Tissue | hsa_circ_0001649 | Up-regulated/ Tumor promotor | qRT-PCR | 0.278 | GAPDH | 0.857 | Yes |
Li XN 2019 [19] | Chinese | 60 | 60 | Adjacent normal mucosa tissues | Plasma | circVAPA | Up-regulated/ Tumor promotor | qRT-PCR/2 − ΔΔCt | Median expression level of circVAPA | U6 | 0.724 | Yes |
Zhuo F 2017 [20] | Chinese | 122 | 122 | Paired noncancerous counterparts | Plasma | circRNA0003906 | Down-regulated/ Tumor suppressor | qRT-PCR/2 − ΔΔCt | / | GAPDH | 0.818 | Yes |