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Table 1 Main characteristics of the meta-analysis for diagnostic performance and clinicopathologic association of circRNAs in CRC

From: A pair-wise meta-analysis highlights circular RNAs as potential biomarkers for colorectal cancer

Study Locale Patient number Control number Control type Sample Type CircRNA signature Expression status/Biological function Method Cut-Off Value Reference gene AUC Assessed clinicopathologic association
Wang J 2018 [9] Chinese 102 102 Adjacent noncancerous tissues Tissue hsa_circ_0000567 Down-regulated/ Tumor suppressor qRT-PCR/2 − ΔΔCt 0.4714 18S rRNA, GAPDH 0.8653 Yes
Wang F 2018 [10] Chinese 46 46 Pair-matched adjacent normal tissues Tissue hsa_circ_0014717 Down-regulated/ Tumor suppressor qRT-PCR/2 − ΔΔCt / GAPDH 0.683 Yes
Wang X 2015 [11] Chinese 62 62 Adjacent normal mucosa Tissue hsa_circ_001988 Down-regulated/ Tumor suppressor qRT-PCR/ΔCt 6.04 GAPDH 0.788 Yes
Hsiao KY 2017 [12]   131 76 Paired noncancerous counterparts Tissue circCCDC66 Up-regulated/ Tumor promotor RNA sequencing / GAPDH 0.88 Yes
Zhang P 2017 [13] Chinese 170 170 Normal colorectal tissue samples Tissue hsa_circRNA_104700 Down-regulated/ Tumor suppressor qRT-PCR/Ct 10.753 GAPDH 0.699 Yes
       hsa_circRNA_103809 Down-regulated/ Tumor suppressor qRT-PCR/Ct 13.9 GAPDH 0.616 Yes
Li J 2018 [14] Chinese 101 101 Paired noncancerous counterparts Tissue hsa_circ_0000711 Down-regulated/ Tumor suppressor qRT-PCR/ΔCt ΔCt: 3.37 GAPDH 0.81 Yes
Ji WX 2018 [16] Chinese 64 64 Paired noncancerous counterparts Tissue hsa_circ_0001649 Up-regulated/ Tumor promotor qRT-PCR 0.278 GAPDH 0.857 Yes
Li XN 2019 [19] Chinese 60 60 Adjacent normal mucosa tissues Plasma circVAPA Up-regulated/ Tumor promotor qRT-PCR/2 − ΔΔCt Median expression level of circVAPA U6 0.724 Yes
Zhuo F 2017 [20] Chinese 122 122 Paired noncancerous counterparts Plasma circRNA0003906 Down-regulated/ Tumor suppressor qRT-PCR/2 − ΔΔCt / GAPDH 0.818 Yes
  1. AUC area under the curve, GAPDH reduced glyceraldehyde-phosphate dehydrogenase, qRT-PCR quantitative reverse transcription-polymerase chain reaction