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Table 1 Main characteristics of the meta-analysis for diagnostic performance and clinicopathologic association of circRNAs in CRC

From: A pair-wise meta-analysis highlights circular RNAs as potential biomarkers for colorectal cancer

Study

Locale

Patient number

Control number

Control type

Sample Type

CircRNA signature

Expression status/Biological function

Method

Cut-Off Value

Reference gene

AUC

Assessed clinicopathologic association

Wang J 2018 [9]

Chinese

102

102

Adjacent noncancerous tissues

Tissue

hsa_circ_0000567

Down-regulated/ Tumor suppressor

qRT-PCR/2 − ΔΔCt

0.4714

18S rRNA, GAPDH

0.8653

Yes

Wang F 2018 [10]

Chinese

46

46

Pair-matched adjacent normal tissues

Tissue

hsa_circ_0014717

Down-regulated/ Tumor suppressor

qRT-PCR/2 − ΔΔCt

/

GAPDH

0.683

Yes

Wang X 2015 [11]

Chinese

62

62

Adjacent normal mucosa

Tissue

hsa_circ_001988

Down-regulated/ Tumor suppressor

qRT-PCR/ΔCt

6.04

GAPDH

0.788

Yes

Hsiao KY 2017 [12]

 

131

76

Paired noncancerous counterparts

Tissue

circCCDC66

Up-regulated/ Tumor promotor

RNA sequencing

/

GAPDH

0.88

Yes

Zhang P 2017 [13]

Chinese

170

170

Normal colorectal tissue samples

Tissue

hsa_circRNA_104700

Down-regulated/ Tumor suppressor

qRT-PCR/Ct

10.753

GAPDH

0.699

Yes

      

hsa_circRNA_103809

Down-regulated/ Tumor suppressor

qRT-PCR/Ct

13.9

GAPDH

0.616

Yes

Li J 2018 [14]

Chinese

101

101

Paired noncancerous counterparts

Tissue

hsa_circ_0000711

Down-regulated/ Tumor suppressor

qRT-PCR/ΔCt

ΔCt: 3.37

GAPDH

0.81

Yes

Ji WX 2018 [16]

Chinese

64

64

Paired noncancerous counterparts

Tissue

hsa_circ_0001649

Up-regulated/ Tumor promotor

qRT-PCR

0.278

GAPDH

0.857

Yes

Li XN 2019 [19]

Chinese

60

60

Adjacent normal mucosa tissues

Plasma

circVAPA

Up-regulated/ Tumor promotor

qRT-PCR/2 − ΔΔCt

Median expression level of circVAPA

U6

0.724

Yes

Zhuo F 2017 [20]

Chinese

122

122

Paired noncancerous counterparts

Plasma

circRNA0003906

Down-regulated/ Tumor suppressor

qRT-PCR/2 − ΔΔCt

/

GAPDH

0.818

Yes

  1. AUC area under the curve, GAPDH reduced glyceraldehyde-phosphate dehydrogenase, qRT-PCR quantitative reverse transcription-polymerase chain reaction