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Table 3 Cox Proportional Hazards Univariate Analysis (N = 158 unless otherwise noted). 95% confidence levels are indicated in the parentheses for the Hazard Ratios (HR)

From: Stromal ColXα1 expression correlates with tumor-infiltrating lymphocytes and predicts adjuvant therapy outcome in ER-positive/HER2-positive breast cancer

Characteristic

HR OS

P OS

HR PFS

P PFS

Clinical Stage

2.0 (1.1–3.4)

0.02

2.1 (1.4–3.3)

< 0.001

Grade

1

1.0

1.1 (0.5–2.3)

0.77

Age

1.08 (1.05–1.1)

< 0.001

1.05 (1.0–1.1)

< 0.001

Lymph Node Status (N = 120)

2.5 (1.4–4.5)

0.002

2.7 (1.6–4.4)

< 0.001

PR status

1.1 (0.4–3.1)

0.83

1.1 (0.5–2.7)

0.76

Stroma

1.1 (0.6–2.3)

0.73

1.1 (0.6–2.0)

0.72

TILs

0.96 (0.92–1.0)

0.027

0.97 (0.9–1.0)

0.025

ColXα1

2.3 (1.3–4.1)

0.006

1.8 (1.2–2.8)

0.008