Characterization and risk association of polymorphisms in Aurora kinases A, B and C with genetic susceptibility to gastric cancer development

Table 6 In silico analysis of the studied polymorphisms

Variant Gene	rs911160 AURKA		rs2289590 AURKB		rs758099 AURKC		rs11084490 AURKC		rs42873 PLK1
Alleles	G	C	C	A	C	T	C	G	G	C
Transcription factors^a	C/EBPalpha C/EBPbeta GR-beta	C/EBPalpha C/EBPbeta GR-beta NF-Y NF-1 NFI-CTF	PEA3 TFII-I YY1	PEA3 TFII-I	NF-1 NF-Y ENKTF-1 XBP-1 CTF POU2F1 PEA3	NF-1 NF-Y TFII-I GATA-1	XBP-1	XBP-1	GR-alpha AP-2alphaA T3R-beta1 c-Jun	GR-alpha AP-2alphaA T3R-beta1

Different transcription factor binding motifs recognized for polymorphic alleles of studied polymorphisms are highlighted in bold characters
^aBinding sites for transcription factors identified by use of PROMO software (ALGGEN web-server)

ISSN: 1471-2407