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Table 6 In silico analysis of the studied polymorphisms

From: Characterization and risk association of polymorphisms in Aurora kinases A, B and C with genetic susceptibility to gastric cancer development

Variant
Gene
rs911160
AURKA
rs2289590
AURKB
rs758099
AURKC
rs11084490
AURKC
rs42873
PLK1
Alleles G C C A C T C G G C
Transcription factorsa C/EBPalpha
C/EBPbeta
GR-beta
C/EBPalpha
C/EBPbeta
GR-beta
NF-Y
NF-1
NFI-CTF
PEA3
TFII-I
YY1
PEA3
TFII-I
NF-1
NF-Y
ENKTF-1
XBP-1
CTF
POU2F1
PEA3
NF-1
NF-Y
TFII-I
GATA-1
XBP-1 XBP-1 GR-alpha
AP-2alphaA
T3R-beta1
c-Jun
GR-alpha
AP-2alphaA
T3R-beta1
  1. Different transcription factor binding motifs recognized for polymorphic alleles of studied polymorphisms are highlighted in bold characters
  2. aBinding sites for transcription factors identified by use of PROMO software (ALGGEN web-server)